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Am J Physiol Gastrointest Liver Physiol. 2015 Mar 15;308(6):G472-81. doi: 10.1152/ajpgi.00098.2014. Epub 2015 Jan 15.

ApoA-IV: current and emerging roles in intestinal lipid metabolism, glucose homeostasis, and satiety.

Author information

1
Department of Nutritional Sciences, University of Connecticut, Storrs, Connecticut alison.kohan@uconn.edu.
2
Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio; and.

Abstract

Apolipoprotein A-IV (apoA-IV) is secreted by the small intestine on chylomicrons into intestinal lymph in response to fat absorption. Many physiological functions have been ascribed to apoA-IV, including a role in chylomicron assembly and lipid metabolism, a mediator of reverse-cholesterol transport, an acute satiety factor, a regulator of gastric function, and, finally, a modulator of blood glucose homeostasis. The purpose of this review is to update our current view of intestinal apoA-IV synthesis and secretion and the physiological roles of apoA-IV in lipid metabolism and energy homeostasis, and to underscore the potential for intestinal apoA-IV to serve as a therapeutic target for the treatment of diabetes and obesity-related disease.

KEYWORDS:

apolipoprotein A-IV (apoA-IV); cardiovascular disease; chylomicron; diabetes; glucose homeostasis; intestinal lipid transport; lymph fistula mouse model; obesity; satiety

PMID:
25591862
PMCID:
PMC4360046
DOI:
10.1152/ajpgi.00098.2014
[Indexed for MEDLINE]
Free PMC Article

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