Send to

Choose Destination
Public Health Nutr. 2015 Oct;18(15):2804-14. doi: 10.1017/S1368980014003115. Epub 2015 Jan 16.

Vitamin E and risk of age-related cataract: a meta-analysis.

Author information

Department of Epidemiology and Health Statistics,Qingdao University Medical College,No. 38 Dengzhou Road,Qingdao 266021,People's Republic of China.



We conducted a meta-analysis to evaluate the relationship between vitamin E and age-related cataract (ARC).


The fixed- or random-effect model was selected based on heterogeneity. Meta-regression was used to explore potential sources of between-study heterogeneity. Publication bias was evaluated using Begg's test. The dose-response relationship was assessed by a restricted cubic spline model.


Relevant studies were identified by a search of PubMed and the Cochrane Library to May 2014, without language restrictions.


Studies involved samples of people of all ages.


Dietary vitamin E intake, dietary and supplemental vitamin E intake, and high serum tocopherol levels were significantly associated with decreased risk of ARC, the pooled relative risk was 0·73 (95% CI 0·58, 0·92), 0·86 (95% CI 0·75, 0·99) and 0·77 (95% CI 0·66, 0·91), respectively. Supplemental vitamin E intake was non-significantly associated with ARC risk (relative risk=0·92; 95% CI 0·78, 1·07). The findings from dose-response analysis showed evidence of a non-linear association between dietary vitamin E intake and ARC. The risk of ARC decreased with dietary vitamin E intake from 7 mg/d (relative risk=0·94; 95% CI 0·90, 0·97).


The findings of the meta-analysis indicated that dietary vitamin E intake, dietary and supplemental vitamin E intake, and high level of serum tocopherol might be significantly associated with reduced ARC risk.


Age-related cataract; Meta-analysis; Serum tocopherol; Vitamin E

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Cambridge University Press
Loading ...
Support Center