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Virulence. 2015;6(4):307-8. doi: 10.1080/21505594.2014.1000752. Epub 2015 Jan 15.

Looking into Candida albicans infection, host response, and antifungal strategies.

Author information

1
a New Drug Research and Development Center; School of Pharmacy ; Second Military Medical University ; Shanghai , China.

Abstract

Candida albicans, a commonly encountered fungal pathogen, causes diseases varying from superficial mucosal complaints to life-threatening systemic disorders. Among the virulence traits of C. albicans, yeast-to-hypha transition is most widely acknowledged. Host innate immunity to C. albicans critically requires pattern recognition receptors (PRRs), and defence against C. albicans infection is provided by an exquisite interplay between the innate and adaptive arms of the host immune system.

KEYWORDS:

Candida albicans; antifungal; immune response

PMID:
25590793
PMCID:
PMC4601349
DOI:
10.1080/21505594.2014.1000752
[Indexed for MEDLINE]
Free PMC Article

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