Format

Send to

Choose Destination
Cell Cycle. 2015;14(3):315-22. doi: 10.4161/15384101.2014.989127.

Active contractility at E-cadherin junctions and its implications for cell extrusion in cancer.

Author information

1
a Divisions of Cell Biology and Molecular Medicine ; The University of Queensland ; St. Lucia , Brisbane , Australia.

Abstract

Cellular contractility regulates tissue cohesion and morphogenesis. In epithelia, E-cadherin adhesion couples the contractile cortices of neighboring cells together to produce tension at junctions that can be transmitted across the epithelium in a planar fashion. We have recently demonstrated that contractility is also patterned in the apical-lateral axis within epithelial junctions. Our findings highlight the role that cytoskeletal regulation plays in controlling the levels of intra-junctional tension. Of note, dysregulation of this apicolateral pattern of tension can drive oncogenic cell extrusion. In this article, we provide a detailed description of the actomyosin cytoskeleton organization during oncogenic extrusion and discuss the implications of cell extrusion in cancer.

KEYWORDS:

E-Cadherin; actin; cell extrusion; myosin; oncogene

PMID:
25590779
PMCID:
PMC4353245
DOI:
10.4161/15384101.2014.989127
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Taylor & Francis Icon for PubMed Central
Loading ...
Support Center