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J Clin Endocrinol Metab. 2015 Feb;100(2):363-70. doi: 10.1210/jc.2014-3421. Epub 2015 Jan 15.

Clinical review: Drugs commonly associated with weight change: a systematic review and meta-analysis.

Author information

1
Knowledge and Evaluation Research Unit (J.P.D., G.P., A.L., M.B.S., O.A., C.U., Z.W., T.E., J.P.B., K.F.M., M.H.L., N.A., J.W., S.F., V.M.M., M.H.M.), Mayo Clinic, Rochester, Minnesota 55905; Unidad de Conocimiento y Evidencia (J.P.D., G.P., V.M.M.), Universidad Peruana Cayetano Heredia, Lima 31, Peru; and Division of Preventive, Occupational, and Aerospace Medicine (N,A., M.H.M.), Division of Endocrinology, Diabetes, Metabolism, and Nutrition (J.P.B., V.M.M.), Division of General Internal Medicine (K.F.M.), and Mayo Clinic Libraries (L.J.P.), Mayo Clinic, Rochester, Minnesota 55905.

Abstract

CONTEXT:

Various drugs affect body weight as a side effect.

OBJECTIVE:

We conducted this systematic review and meta-analysis to summarize the evidence about commonly prescribed drugs and their association with weight change.

DATA SOURCES:

MEDLINE, DARE, and the Cochrane Database of Systematic Reviews were searched to identify published systematic reviews as a source for trials.

STUDY SELECTION:

We included randomized trials that compared an a priori selected list of drugs to placebo and measured weight change.

DATA EXTRACTION:

We extracted data in duplicate and assessed the methodological quality using the Cochrane risk of bias tool.

RESULTS:

We included 257 randomized trials (54 different drugs; 84 696 patients enrolled). Weight gain was associated with the use of amitriptyline (1.8 kg), mirtazapine (1.5 kg), olanzapine (2.4 kg), quetiapine (1.1 kg), risperidone (0.8 kg), gabapentin (2.2 kg), tolbutamide (2.8 kg), pioglitazone (2.6 kg), glimepiride (2.1 kg), gliclazide (1.8 kg), glyburide (2.6 kg), glipizide (2.2 kg), sitagliptin (0.55 kg), and nateglinide (0.3 kg). Weight loss was associated with the use of metformin (1.1 kg), acarbose (0.4 kg), miglitol (0.7 kg), pramlintide (2.3 kg), liraglutide (1.7 kg), exenatide (1.2 kg), zonisamide (7.7 kg), topiramate (3.8 kg), bupropion (1.3 kg), and fluoxetine (1.3 kg). For many other remaining drugs (including antihypertensives and antihistamines), the weight change was either statistically nonsignificant or supported by very low-quality evidence.

CONCLUSIONS:

Several drugs are associated with weight change of varying magnitude. Data are provided to guide the choice of drug when several options exist and institute preemptive weight loss strategies when obesogenic drugs are prescribed.

PMID:
25590213
PMCID:
PMC5393509
DOI:
10.1210/jc.2014-3421
[Indexed for MEDLINE]
Free PMC Article

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