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J Thorac Dis. 2014 Dec;6(12):E272-5. doi: 10.3978/j.issn.2072-1439.2014.11.36.

Primary malignant pericardial mesothelioma-a rare cause of superior vena cava thrombosis and constrictive pericarditis.

Author information

1
1 Department of Cardiac Surgery, Ruijin Hospital of Shanghai Jiaotong University School of Medicine, Shanghai 200025, China ; 2 Department of Cardio-thoracic Surgery, the Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China.

Abstract

Primary malignant pericardial mesothelioma (PMPM) is an extremely rare, highly lethal and often misdiagnosed tumor. We report a 60-year-old woman complaining of dry cough, shortness of breath and exertional dyspnea due to a large pericardial effusion. The pericardial fluid volume declined after pericardiocentesis; analysis of the fluid revealed malignant cells and was negative for tuberculosis. Subsequently, the patient developed a compression of the superior vena cava and pericardial constriction. The patient's symptoms marginally improved after partial pericardiectomy, and a diagnosis of pericardial mesothelioma was made on pathology. However, her symptoms continued to aggravate, and she died 8 months after presentation. Pericardial mesothelioma should be discovered earlier to treat patients who develop repeatedly pericardial effusion after pericardiocentesis and pericardial tamponade or those develop constrictive pericarditis.

KEYWORDS:

Pericardial mesothelioma; constrictive pericarditis; superior vena cava thrombosis

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