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Curr Opin Microbiol. 2015 Apr;24:1-6. doi: 10.1016/j.mib.2014.12.004. Epub 2015 Jan 10.

Oxidative stress protection by polyphosphate--new roles for an old player.

Author information

1
Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: mikegray@umich.edu.
2
Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA; Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: ujakob@umich.edu.

Abstract

Inorganic polyphosphate is a universally conserved biopolymer whose association with oxidative stress resistance has been documented in many species, but whose mode of action has been poorly understood. Here we review the recent discovery that polyphosphate functions as a protein-protective chaperone, examine the mechanisms by which polyphosphate-metal ion interactions reduce oxidative stress, and summarize polyphosphate's roles in regulating general stress response pathways. Given the simple chemical structure and ancient pedigree of polyphosphate, these diverse mechanisms are likely to be broadly relevant in many organisms, from bacteria to mammalian cells.

PMID:
25589044
PMCID:
PMC4380828
DOI:
10.1016/j.mib.2014.12.004
[Indexed for MEDLINE]
Free PMC Article

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