Format

Send to

Choose Destination
J Neuroimaging. 2015 Sep-Oct;25(5):807-12. doi: 10.1111/jon.12191. Epub 2015 Jan 15.

Optic Neuritis and the Visual Pathway: Evaluation of Neuromyelitis Optica Spectrum by Resting-State fMRI and Diffusion Tensor MRI.

Author information

1
Federal University of Rio de Janeiro, Radiology, Rua Presidente João Pessoa, Niterói, Rio de Janeiro, Brazil.
2
Federal University of Rio de Janeiro, Neurology, Rio de Janeiro, Rio de Janeiro, Brazil.
3
State University of Rio de Janeiro, Neurology, Rio de Janeiro, Rio de Janeiro, Brazil.

Abstract

BACKGROUND AND PURPOSE:

Optic neuritis (ON) is an acute episode of inflammation in the visual pathway (VP). It may occur as part of a demyelinating disease, which can affect white matter (WM) throughout the VP. Compensatory cortical adaptations may occur following WM damage to maintain visual integrity. Our aim was to investigate whether resting-state functional MRI (rsfMRI) can detect cortical adaptations following ON attacks and to correlate rsfMRI with diffusion tensor imaging (DTI) of WM within the VP.

MATERIALS AND METHODS:

Neuromyelitis optica spectrum patients were compared to healthy controls at least 6 months after ON onset. DTI and rsfMRI were performed and post-processed using FSL tools (TBSS for DTI and MELODIC for fMRI).

RESULTS:

Ptients had higher synchronization values than controls in the visual network (3.48 vs. 2.12, P < .05). A weak trend of correlation was revealed between fMRI and structural analysis by DTI using fractional anisotropy (right side: R = -.36, P < .08; left side: R = .075, P < .73).

CONCLUSIONS:

The rsfMRI detected cortical reorganization following ON attack, but WM was considerably preserved in the posterior VP.

KEYWORDS:

MRI; Neuromyelitis optica; diffusion tensor imaging; neuritis optica; resting-state functional

PMID:
25588974
DOI:
10.1111/jon.12191
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center