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J Cardiovasc Electrophysiol. 2015 Apr;26(4):385-389. doi: 10.1111/jce.12619. Epub 2015 Feb 26.

Pulmonary vein isolation for atrial fibrillation in the postpneumonectomy population: a feasibility, safety, and outcomes study.

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Division of Cardiology, Creighton University, Omaha, Nebraska, USA.
Division of Cardiology, Case Western Reserve University, MetroHealth Medical Center, Cleveland, Ohio, USA.
KU Cardiovascular Research Institute, The University of Kansas Hospital and Medical Center, Kansas City, Kansas, USA.
Division of Cardiology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Division of Cardiology, Albert Einstein Montefiore Medical Center, Bronx, New York, USA.
Division of Cardiology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Division of Cardiology, Howard University Hospital, Washington, District of Columbia, USA.
Division of Cardiology, Intermountain Heart Institute, Salt Lake City, Utah, USA.
Division of Electrophysiology, Texas Cardiac Arrhythmia Institute, St. David's Medical Center, Austin, Texas, USA.



Pulmonary vein isolation (PVI) of the remnant pulmonary vein (PV) stumps in pneumonectomy patients has not been well characterized.


This is a multicenter observational study of patients with a remnant PV stump after pneumonectomy. Consecutive patients with a history of pneumonectomy and who had undergone RF ablation for drug refractory AF were identified from the AF database at the participating institutions.


There were 15 patients in whom pneumonectomy was performed, for resection of tumors in 10, infection in 4, and bullae in 1 patient and who underwent RF ablation for AF. The mean age was 63 ± 7 years. The stumps were from the right lower PV in 5, left upper PV in 5, left lower PV in 3, and right upper PV in 2 patients. All the PV stumps were electrically active with PV potentials and 9 (60%) of them had triggered activity. PVI was performed in 14 and focal isolation in 1 patient. At 1-year follow-up, 80% were free of AF, off of antiarrhythmic medications.


PV stumps in AF patients with previous pneumonectomy are electrically active and are frequently the sites of active firing. Isolation of these PV stumps can be accomplished safely and effectively using catheter ablation with no practical concern for PV stenosis or compromising PV stump integrity.


atrial fibrillation ablation; atrial fibrillation after pneumonectomy; catheter ablation of pulmonary vein stump; efficacy of isolation of pulmonary vein stump; pulmonary vein stump

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