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Curr Opin Cell Biol. 2015 Apr;33:88-94. doi: 10.1016/j.ceb.2014.12.005. Epub 2015 Jan 10.

Epigenetic modulation of metabolic decisions.

Author information

1
Department of Clinical and Experimental Medicine, Linkoping University, 58183 Linkoping, Sweden.
2
Max Planck Institute of Immunobiology and Epigenetics, Stuebeweg 51, 79108 Freiburg, Germany. Electronic address: pospisilik@ie-freiburg.mpg.de.

Abstract

In the recent years there has been a tremendous increase in our understanding of chromatin, transcription and the importance of metabolites in their regulation. This review highlights what is currently sparse information that suggest existence of a refined system integrating metabolic and chromatin control. We indicate possible regulatory modes, such as feed forward amplification, that may help effect and stabilize long-lasting phenotypic decisions within and even across generations using adipogenesis as the primary context.

PMID:
25588618
DOI:
10.1016/j.ceb.2014.12.005
[Indexed for MEDLINE]

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