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Nat Prod Res. 2015;29(22):2100-2. doi: 10.1080/14786419.2014.986659. Epub 2015 Jan 14.

Antigiardial activity of glycoproteins and glycopeptides from Ziziphus honey.

Author information

1
a Environment and Natural Resources Research Institute, National Centre for Research , P.O. Box 6096, Khartoum , Sudan.
2
b Medicinal and Aromatic Plants Research Institute, National Centre for Research , P.O. Box 2404, Khartoum , Sudan.
3
c H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi , Karachi 75270 , Pakistan.

Abstract

Natural honey contains an array of glycoproteins, proteoglycans and glycopeptides. Size-exclusion chromatography fractionated Ziziphus honey proteins into five peaks with molecular masses in the range from 10 to >200 kDa. The fractionated proteins exhibited in vitro activities against Giardia lamblia with IC50 values ≤ 25 μg/mL. Results indicated that honey proteins were more active as antiprotozoal agents than metronidazole. This study indicated the potential of honey proteins and peptides as novel antigiardial agents.

KEYWORDS:

Giardia lamblia; antiprotozoal; honey proteins

PMID:
25587739
DOI:
10.1080/14786419.2014.986659
[Indexed for MEDLINE]

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