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Annu Rev Med. 2015;66:311-28. doi: 10.1146/annurev-med-051113-024537.

The JAK-STAT pathway: impact on human disease and therapeutic intervention.

Author information

1
Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892; email: osheajo@mail.nih.gov.

Abstract

The Janus kinase (JAK)-signal transducer of activators of transcription (STAT) pathway is now recognized as an evolutionarily conserved signaling pathway employed by diverse cytokines, interferons, growth factors, and related molecules. This pathway provides an elegant and remarkably straightforward mechanism whereby extracellular factors control gene expression. It thus serves as a fundamental paradigm for how cells sense environmental cues and interpret these signals to regulate cell growth and differentiation. Genetic mutations and polymorphisms are functionally relevant to a variety of human diseases, especially cancer and immune-related conditions. The clinical relevance of the pathway has been confirmed by the emergence of a new class of therapeutics that targets JAKs.

KEYWORDS:

autoimmunity; cancer; cytokine; immunodeficiency; kinase inhibitors

PMID:
25587654
PMCID:
PMC5634336
DOI:
10.1146/annurev-med-051113-024537
[Indexed for MEDLINE]
Free PMC Article

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