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J Med Microbiol. 2015 Mar;64(Pt 3):243-7. doi: 10.1099/jmm.0.000012. Epub 2015 Jan 13.

High prevalence of Escherichia coli sequence type 131 among antimicrobial-resistant E. coli isolates from geriatric patients.

Author information

1
Department of Microbiology and Carol Yu Centre for Infection, University of Hong Kong, Hong Kong SAR, PR China plho@hkucc.hku.hk.
2
Department of Clinical Pathology, Tuen Mun Hospital, Hong Kong SAR, PR China.
3
Department of Microbiology and Carol Yu Centre for Infection, University of Hong Kong, Hong Kong SAR, PR China.
4
Department of Clinical Pathology, Kwong Wah Hospital, Hong Kong SAR, PR China.
5
Department of Clinical Pathology, Princess Margaret Hospital, Hong Kong SAR, PR China.

Abstract

Previous work on the subclones within Escherichia coli ST131 predominantly involved isolates from Western countries. This study assessed the prevalence and antimicrobial resistance attributed to this clonal group. A total of 340 consecutive, non-duplicated urinary E. coli isolates originating from four clinical laboratories in Hong Kong in 2013 were tested. ST131 prevalence among the total isolates was 18.5 % (63/340) and was higher among inpatient isolates (23.0 %) than outpatient isolates (11.8 %, P<0.001), and higher among isolates from patients aged ≥65 years than from patients aged 18-50 years and 51-64 years (25.4 vs 3.4 and 4.0 %, respectively, P<0.001). Of the 63 ST131 isolates, 43 (68.3 %) isolates belonged to the H30 subclone, whereas the remaining isolates belonged to H41 (n = 17), H54 (n = 2) and H22 (n = 1). All H30 isolates were ciprofloxacin-resistant, of which 18.6 % (8/43) belonged to the H30-Rx subclone. Twenty-six (41.3 %) ST131 isolates were ESBL-producers, of which 19 had blaCTX-M-14 (12 non-H30-Rx, two H30-Rx and five H41), six had blaCTX-M-15 (five non-H30-Rx and one H30-Rx) and one was blaCTX-M-negative (H30). In conclusion, ST131 accounts for a large share of the antimicrobial-resistant E. coli isolates from geriatric patients. Unlike previous reports, ESBL-producing ST131 strains mainly belonged to non-H30-Rx rather than the H30-Rx subclone, with blaCTX-M-14 as the dominant enzyme type.

PMID:
25587081
DOI:
10.1099/jmm.0.000012
[Indexed for MEDLINE]

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