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Asia Pac Psychiatry. 2015 Sep;7(3):286-91. doi: 10.1111/appy.12172. Epub 2015 Jan 14.

Brain area-related neurological soft signs in depressive patients with different types of childhood maltreatment.

Zhao H1,2, Guo W1,2, Niu W1,2, Zhong A1,2, Zhou X3.

Author information

1
Department of Psychiatry, No.102 Hospital of People's Liberation Army, Changzhou, China.
2
Department of Psychology, Chang Zhou Peace Hospital, Changzhou, China.
3
Department of Neurology, Laboratory of Neurological Diseases, Changzhou No.2 People's Hospital, The Affiliated Hospital of Nanjing Medical University, Changzhou, China.

Abstract

INTRODUCTION:

This study aims to investigate the effects of childhood maltreatment on neurological soft signs (NSS) associated with certain brain area in depressive patients.

METHODS:

One hundred three depressive patients were enrolled into this study, and evaluated by Childhood Trauma Questionnaire (CTQ), brain area-related neurological examination scale, 24-item Hamilton Rating scale (HAMD24), the scale for suicidal ideation (SSI) and Beck Hopelessness Scale (BHS).

RESULTS:

Patients undergoing childhood maltreatment exhibited higher frontal area-related NSS scores than patients without childhood maltreatment experience. Patients experiencing childhood emotional or physical neglect displayed more frontal area-related NSS compared to their respective non-maltreatment group. Moreover, physical neglect maltreatment caused more temporal area-related NSS. Patients suffering from childhood sexual abuse had more frontal, temporal and occipital area-related NSS than patients lacking experience of childhood sexual abuse. Further correlation analysis revealed that the total score of maltreatment positively correlated with frontal and temporal area-related NSS score. There was a positive correlation between emotional abuse, emotional neglect or physical abuse and frontal area-related NSS. Physical neglect and sexual abuse were positively associated with the temporal area-related NSS score. HAMD24 score was positively correlated with all brain area-related NSS score; The SSI score correlated with three area (excluded occipital area)-related NSS score. The BHS score only positively correlated with frontal area score of NSS. Finally, no significant association was found between suicidal frequencies and brain area-related NSS score.

DISCUSSION:

Childhood maltreatment adversely affects the brain of depressive patients; the different maltreatment may impair different brain areas, especially frontal and temporal areas.

KEYWORDS:

brain area; childhood maltreatment; depression; neurological soft sign

PMID:
25586928
DOI:
10.1111/appy.12172
[Indexed for MEDLINE]

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