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Pediatr Blood Cancer. 2015 Apr;62(4):565-70. doi: 10.1002/pbc.25403. Epub 2015 Jan 13.

A practical approach to reporting treatment abandonment in pediatric chronic conditions.

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St Jude Children's Research Hospital, Memphis, Tennessee.


Treatment abandonment, the failure to complete therapy that is required for definitive disease control, frequently causes treatment failure for pediatric patients in low- and middle-income countries with chronic conditions, particularly cancer. Other forms of incomplete treatment affecting children in all settings, such as nonadherence and loss to follow-up, are often confused with treatment abandonment. Unclear definitions of incomplete treatment dramatically affect reported outcomes. To facilitate disease-specific and cross-sector analyses, we outline a practical approach to categorize forms of incomplete treatment, present distinct semantic categories with case examples and provide an algorithm that could be tailored to disease- and context-specific needs.


adherence; chronic disease; loss to follow-up; outcome evaluation; treatment abandonment; treatment failure

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