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Dev Cell. 2015 Jan 12;32(1):5-6. doi: 10.1016/j.devcel.2014.12.022.

Global resource distribution: allocation of actin building blocks by profilin.

Author information

1
Biology Department, Brandeis University, Waltham, MA 02453, USA.
2
Biology Department, Brandeis University, Waltham, MA 02453, USA. Electronic address: goode@brandeis.edu.

Abstract

How cells regulate the distribution of a limited pool of actin between two competing structures has long been a mystery. Complementary studies from Suarez et al. (2015) and Rotty et al. (2015) now show that profilin controls the partitioning of actin monomers between competing actin networks assembled by Arp2/3 complex and formins or Ena/VASP.

PMID:
25584793
DOI:
10.1016/j.devcel.2014.12.022
[Indexed for MEDLINE]
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