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Mol Plant Microbe Interact. 2015 May;28(5):511-8. doi: 10.1094/MPMI-10-14-0322-CR.

14-3-3 proteins in plant-pathogen interactions.

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1The Sainsbury Laboratory, Norwich Research Park, NR4 7UH Norwich, U.K.;
2Shanghai Center for Plant Stress Biology, Chinese Academy of Sciences, 3888 Chenhua Rd, Shanghai 201602, China.


14-3-3 proteins define a eukaryotic-specific protein family with a general role in signal transduction. Primarily, 14-3-3 proteins act as phosphosensors, binding phosphorylated client proteins and modulating their functions. Since phosphorylation regulates a plethora of different physiological responses in plants, 14-3-3 proteins play roles in multiple signaling pathways, including those controlling metabolism, hormone signaling, cell division, and responses to abiotic and biotic stimuli. Increasing evidence supports a prominent role of 14-3-3 proteins in regulating plant immunity against pathogens at various levels. In this review, potential links between 14-3-3 function and the regulation of plant-pathogen interactions are discussed, with a special focus on the regulation of 14-3-3 proteins in response to pathogen perception, interactions between 14-3-3 proteins and defense-related proteins, and 14-3-3 proteins as targets of pathogen effectors.

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