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ACS Nano. 2015 Jan 27;9(1):860-8. doi: 10.1021/nn506544b. Epub 2015 Jan 13.

Highly angiogenic peptide nanofibers.

Author information

1
Department of Chemistry and Department of Bioengineering, Rice University Mail Stop 602, 6100 Main Street, Houston, Texas 77030, United States.

Abstract

Major limitations of current tissue regeneration approaches using artificial scaffolds are fibrous encapsulation, lack of host cellular infiltration, unwanted immune responses, surface degradation preceding biointegration, and artificial degradation byproducts. Specifically, for scaffolds larger than 200-500 μm, implants must be accompanied by host angiogenesis in order to provide adequate nutrient/waste exchange in the newly forming tissue. In the current work, we design a peptide-based self-assembling nanofibrous hydrogel containing cell-mediated degradation and proangiogenic moieties that specifically address these challenges. This hydrogel can be easily delivered by syringe, is rapidly infiltrated by cells of hematopoietic and mesenchymal origin, and rapidly forms an extremely robust mature vascular network. Scaffolds show no signs of fibrous encapsulation and after 3 weeks are resorbed into the native tissue. These supramolecular assemblies may prove a vital paradigm for tissue regeneration and specifically for ischemic tissue disease.

KEYWORDS:

angiogenesis; multidomain peptide; self-assembly; supramolecular chemistry

PMID:
25584521
PMCID:
PMC4370274
DOI:
10.1021/nn506544b
[Indexed for MEDLINE]
Free PMC Article

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