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Mult Scler. 2015 Oct;21(11):1423-30. doi: 10.1177/1352458514564484. Epub 2015 Jan 12.

Low intensity lympho-ablative regimen followed by autologous hematopoietic stem cell transplantation in severe forms of multiple sclerosis: A MRI-based clinical study.

Author information

1
Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health; University of Genova; Italy.
2
Careggi University Hospital, University of Firenze, Italy.
3
Bone Marrow Transplantation Unit, San Martino Hospital, Genova, Italy.
4
Department of Health Sciences and MRI Center for neurological diseases, University of Genova, Italy.
5
Department of Health Sciences, University of Genova, Italy.
6
Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health; University of Genova; Italy/Department of Health Sciences, University of Genova, Italy glmancardi@neurologia.unige.it.

Abstract

BACKGROUND:

Autologous hematopoietic stem cell transplantation (AHSCT) has been successfully used to treat aggressive forms of multiple sclerosis (MS) that are unresponsive to approved therapies. In the last years, in view of the risk of mortality related to the procedure, the utilization of low-intensity conditioning regimens has been considered.

OBJECTIVE:

To report magnetic resonance imaging (MRI) and clinical data in a small cohort of patients treated with a low-intensity lympho-ablative regimen, followed by AHSCT.

METHODS:

Seven patients affected by relapsing-remitting MS (RRMS) underwent AHSCT, with cyclophosphamide 120 mg/kg in 2 days as the conditioning regimen; and were then followed with serial MRI evaluations until 36 months, with clinical evaluations until 60 months.

RESULTS:

The mean number of gadolinium (Gd)-enhancing lesions significantly decreased after treatment, but a complete suppression of inflammatory activity was not obtained. No deaths occurred, but every patient developed adverse events, although not severe. After 5 years of follow-up, two patients remained stable, one patient markedly improved and four patients had a mild progression of the disease. Only one patient experienced a relapse after treatment.

CONCLUSION:

A low-intensity conditioning regimen with AHSCT has a profound effect on MRI inflammation and relapses, but is not able to completely abrogate MRI activity and disease progression of aggressive RRMS.

KEYWORDS:

Aggressive multiple sclerosis; autologous hematopoietic stem cell transplantation; conditioning regimen; lympho-ablation; multiple sclerosis; relapsing–remitting multiple sclerosis; transplantation; treatment methods

PMID:
25583838
DOI:
10.1177/1352458514564484
[Indexed for MEDLINE]

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