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Amino Acids. 2015 Apr;47(4):779-85. doi: 10.1007/s00726-014-1908-7. Epub 2015 Jan 13.

A direct method for the synthesis of orthogonally protected furyl- and thienyl- amino acids.

Author information

1
Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, UK.

Abstract

The synthesis of unnatural amino acids plays a key part in expanding the potential application of peptide-based drugs and in the total synthesis of peptide natural products. Herein, we report a direct method for the synthesis of orthogonally protected 5-membered heteroaromatic amino acids.

PMID:
25583604
DOI:
10.1007/s00726-014-1908-7
[Indexed for MEDLINE]

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