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Mol Endocrinol. 1989 Sep;3(9):1455-61.

Identification of a cDNA encoding a long form of prolactin receptor in human hepatoma and breast cancer cells.

Author information

1
Laboratory of Molecular Endocrinology, McGill University, Royal Victoria Hospital, Montreal, Canada.

Abstract

Human PRL receptor cDNA clones from hepatoma (Hep G2) and breast cancer (T-47D) libraries were isolated by using a rat PRL receptor cDNA probe. The nucleotide sequence predicts a mature protein of 598 amino acids with a much longer cytoplasmic domain than the rat liver PRL receptor. Although this extended region has additional segments of localized sequence identity with the human GH receptor, there is no identity with any consensus sequences known to be involved in hormonal signal transduction. This cDNA will be a valuable tool to better understand the role of PRL in the development and growth of human breast cancer.

PMID:
2558309
DOI:
10.1210/mend-3-9-1455
[Indexed for MEDLINE]

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