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Ann Biol Clin (Paris). 2015 Jan-Feb;73(1):25-37. doi: 10.1684/abc.2014.1007.

[Blood sampling using "dried blood spot": a clinical biology revolution underway?].

[Article in French]

Author information

Institut de recherche en biothérapie, Hôpital Saint Eloi, CHU Montpellier, France ; Laboratoire de biochimie clinique de la protéomique et CCBHM, Université Montpellier 1, Montpellier, France ; Inserm, F-34000 U1040, Montpellier, France.


Blood testing using the dried blood spot (DBS) is used since the 1960s in clinical analysis, mainly within the framework of the neonatal screening (Guthrie test). Since then numerous analytes such as nucleic acids, small molecules or lipids, were successfully measured on the DBS. While this pre-analytical method represents an interesting alternative to classic blood sampling, its use in routine is still limited. We review here the different clinical applications of the blood sampling on DBS and estimate its future place, supported by the new methods of analysis as the LC-MS mass spectrometry.


ELISA; PCR; dried blood spot; mass spectrometry; multiplex; pre-analytical

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