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J Am Acad Dermatol. 2015 Mar;72(3):485-8. doi: 10.1016/j.jaad.2014.11.017. Epub 2015 Jan 10.

Correlation of early-onset hidradenitis suppurativa with stronger genetic susceptibility and more widespread involvement.

Author information

1
Department of Dermatology, Erasmus University Medical Center, Rotterdam, The Netherlands; Department of Immunology, Erasmus University Medical Center, Rotterdam, The Netherlands. Electronic address: i.deckers@erasmusmc.nl.
2
Department of Dermatology, Erasmus University Medical Center, Rotterdam, The Netherlands.
3
Department of Dermatology, Deventer Hospital, Deventer, The Netherlands.
4
Department of Dermatology, Erasmus University Medical Center, Rotterdam, The Netherlands; Department of Immunology, Erasmus University Medical Center, Rotterdam, The Netherlands.

Abstract

BACKGROUND:

The reported mean age of onset of hidradenitis suppurativa (HS) is between 20 and 24 years. Prepubertal onset is thought to be rare.

OBJECTIVE:

We sought to determine the prevalence of early-onset HS and to compare clinical characteristics between early-onset and normal-onset HS in a retrospective study.

METHODS:

Data were collected from 855 patients with HS. Early-onset HS was defined as onset before the thirteenth birthday. Clinical characteristics were analyzed in relation to the age of onset.

RESULTS:

In all, 66 patients (7.7%) reported early-onset HS. A family history for HS was significantly higher in early-onset patients (55.6% vs 34.2%; odds ratio 2.1, 95% confidence interval 1.2-3.6, P = .006). They developed inflammatory lesions at more body sites than patients with normal-onset HS (odds ratio 3.0, 95% confidence interval 1.8-4.9, P < .001). Distribution of the Hurley stages of severity showed no differences between the 2 groups (odds ratio 1.1, 95% confidence interval 0.7-1.8, P = .72).

LIMITATIONS:

Some data were based on patient-reported information.

CONCLUSION:

Early-onset HS occurs more frequently than previously believed. Patients with early-onset HS often report a family history for HS and develop lesions at more body sites.

KEYWORDS:

acne ectopica; acne inversa; age of onset; disease extent; disease severity; early onset; family history; genetic predisposition; hidradenitis suppurativa

PMID:
25582541
DOI:
10.1016/j.jaad.2014.11.017
[Indexed for MEDLINE]

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