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Neuropharmacology. 2015 Jul;94:42-8. doi: 10.1016/j.neuropharm.2014.12.010. Epub 2015 Jan 9.

Two aspects of ASIC function: Synaptic plasticity and neuronal injury.

Author information

1
School of Pharmacy, Anhui Medical University, Hefei, China; Neuroscience Institute, Morehouse School of Medicine, Atlanta GA 30310, USA.
2
Department of Physiology and Cell Biology, University of South Alabama College of Medicine, Mobile, AL 36688, USA; Lab of Neuropharmacology and Neurotoxicology, Shanghai University, Shanghai, China.
3
School of Pharmacy, Anhui Medical University, Hefei, China.
4
Lab of Neuropharmacology and Neurotoxicology, Shanghai University, Shanghai, China.
5
Neuroscience Institute, Morehouse School of Medicine, Atlanta GA 30310, USA. Electronic address: zxiong@msm.edu.
6
Department of Physiology and Cell Biology, University of South Alabama College of Medicine, Mobile, AL 36688, USA. Electronic address: zha@southalabama.edu.

Abstract

Extracellular brain pH fluctuates in both physiological and disease conditions. The main postsynaptic proton receptor is the acid-sensing ion channels (ASICs). During the past decade, much progress has been made on protons, ASICs, and neurological disease. This review summarizes the recent progress on synaptic role of protons and our current understanding of how ASICs contribute to various types of neuronal injury in the brain. This article is part of the Special Issue entitled 'Acid-Sensing Ion Channels in the Nervous System'.

KEYWORDS:

ASIC; Acidosis; Neuronal injury; Proton; Synaptic plasticity

PMID:
25582290
PMCID:
PMC4458418
DOI:
10.1016/j.neuropharm.2014.12.010
[Indexed for MEDLINE]
Free PMC Article

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