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J Sci Food Agric. 2015 Oct;95(13):2763-71. doi: 10.1002/jsfa.7078. Epub 2015 Feb 19.

Petroselinum crispum has antioxidant properties, protects against DNA damage and inhibits proliferation and migration of cancer cells.

Author information

1
Centre for Natural Products and Drug Discovery (CENAR) and Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.

Abstract

BACKGROUND:

Petroselinum crispum (English parsley) is a common herb of the Apiaceae family that is cultivated throughout the world and is widely used as a seasoning condiment. Studies have shown its potential as a medicinal herb. In this study, P. crispum leaf and stem extracts were evaluated for their antioxidant properties, protection against DNA damage in normal 3T3-L1 cells, and the inhibition of proliferation and migration of the MCF-7 cells.

RESULTS:

The dichloromethane extract of P. crispum exhibited the highest phenolic content (42.31 ± 0.50 mg GAE g(-1) ) and ferric reducing ability (0.360 ± 0.009 mmol g(-1) ) of the various extractions performed. The extract showed DPPH radical scavenging activity with an IC50 value of 3310.0 ± 80.5 µg mL(-1) . Mouse fibroblasts (3T3-L1) pre-treated with 400 µg mL(-1) of the extract showed 50.9% protection against H2 O2 -induced DNA damage, suggesting its potential in cancer prevention. The extract (300 µg mL(-1) ) inhibited H2 O2 -induced MCF-7 cell migration by 41% ± 4%. As cell migration is necessary for metastasis of cancer cells, inhibition of migration is an indication of protection against metastasis.

CONCLUSION:

Petroselinum crispum has health-promoting properties with the potential to prevent oxidative stress-related diseases and can be developed into functional food.

KEYWORDS:

DNA protection; MCF-7 cell migration; Petroselinum crispum; antioxidant activity; antiproliferative activity; hydrogen peroxide

PMID:
25582089
PMCID:
PMC5024025
DOI:
10.1002/jsfa.7078
[Indexed for MEDLINE]
Free PMC Article

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