The BCL2 antagonist ABT-199 triggers apoptosis, and augments ibrutinib and idelalisib mediated cytotoxicity in CXCR4 Wild-type and CXCR4 WHIM mutated Waldenstrom macroglobulinaemia cells

Br J Haematol. 2015 Jul;170(1):134-8. doi: 10.1111/bjh.13278. Epub 2015 Jan 12.

Authors

Yang Cao^{1

2}, Guang Yang^{1

2}, Zachary R Hunter^{1

3

4}, Xia Liu^{1

2}, Lian Xu¹, Jie Chen¹, Nickolas Tsakmaklis¹, Evdoxia Hatjiharissi^{3

4}, Sandra Kanan¹, Matthew S Davids^{1

2}, Jorge J Castillo^{1

2}, Steven P Treon^{5

6}

Affiliations

¹ Bing Center for Waldenstrom's Macroglobulinemia, Dana Farber Cancer Institute, Boston, MA, USA.
² Department of Medicine, Harvard Medical School, Boston, MA, USA.
³ Department of Pathology, Boston University Medical Center, Boston, MA, USA.
⁴ Theagenio Cancer Hospital, Thessaloniki, Greece.
⁵ Bing Center for Waldenstrom's Macroglobulinemia, Dana Farber Cancer Institute, Boston, MA, USA. steven_treon@dfci.harvard.edu.
⁶ Department of Medicine, Harvard Medical School, Boston, MA, USA. steven_treon@dfci.harvard.edu.

PMID: 25582069
DOI: 10.1111/bjh.13278

No abstract available

Keywords: ABT-199; BCL2; CXCR4; Ibrutinib; Waldenström macroglobulinemia.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adenine / analogs & derivatives
Antineoplastic Combined Chemotherapy Protocols / pharmacology*
Apoptosis / drug effects
Apoptosis Regulatory Proteins / genetics*
Apoptosis Regulatory Proteins / metabolism
Bcl-2-Like Protein 11
Bridged Bicyclo Compounds, Heterocyclic / administration & dosage
Bridged Bicyclo Compounds, Heterocyclic / pharmacology*
Drug Synergism
Humans
Membrane Proteins / genetics*
Membrane Proteins / metabolism
Piperidines
Proto-Oncogene Proteins / genetics*
Proto-Oncogene Proteins / metabolism
Purines / administration & dosage
Purines / pharmacology*
Pyrazoles / administration & dosage
Pyrazoles / pharmacology*
Pyrimidines / administration & dosage
Pyrimidines / pharmacology*
Quinazolinones / administration & dosage
Quinazolinones / pharmacology*
Receptors, CXCR4 / genetics*
Receptors, CXCR4 / metabolism
Sulfonamides / administration & dosage
Sulfonamides / pharmacology*
Waldenstrom Macroglobulinemia / drug therapy*
Waldenstrom Macroglobulinemia / genetics
Waldenstrom Macroglobulinemia / metabolism
Waldenstrom Macroglobulinemia / pathology

Substances

Apoptosis Regulatory Proteins
BCL2L11 protein, human
Bcl-2-Like Protein 11
Bridged Bicyclo Compounds, Heterocyclic
CXCR4 protein, human
Membrane Proteins
Piperidines
Proto-Oncogene Proteins
Purines
Pyrazoles
Pyrimidines
Quinazolinones
Receptors, CXCR4
Sulfonamides
ibrutinib
Adenine
venetoclax
idelalisib