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Trends Immunol. 2015 Feb;36(2):112-20. doi: 10.1016/j.it.2014.12.003. Epub 2015 Jan 9.

Exploiting host immunity: the Salmonella paradigm.

Author information

1
Department of Microbiology and Molecular Genetics, University of California, Irvine School of Medicine, Irvine, CA 92697-4025, USA; Institute for Immunology, University of California, Irvine School of Medicine, Irvine, CA 92697-4025, USA.
2
Department of Microbiology and Molecular Genetics, University of California, Irvine School of Medicine, Irvine, CA 92697-4025, USA.
3
Department of Microbiology and Molecular Genetics, University of California, Irvine School of Medicine, Irvine, CA 92697-4025, USA; Institute for Immunology, University of California, Irvine School of Medicine, Irvine, CA 92697-4025, USA. Electronic address: manuelar@uci.edu.

Abstract

Pathogens have evolved clever strategies to evade and in some cases exploit the attacks of an activated immune system. Salmonella enterica is one such pathogen, exploiting multiple aspects of host defense to promote its replication in the host. Here we review recent findings on the mechanisms by which Salmonella establishes systemic and chronic infection, including strategies involving manipulation of innate immune signaling and inflammatory forms of cell death, as well as immune evasion by establishing residency in M2 macrophages. We also examine recent evidence showing that the oxidative environment and the high levels of antimicrobial proteins produced in response to localized Salmonella gastrointestinal infection enable the pathogen to successfully outcompete the resident gut microbiota.

KEYWORDS:

Salmonella; immune evasion; immunity; inflammation; mucosal immunity

PMID:
25582038
PMCID:
PMC4323876
DOI:
10.1016/j.it.2014.12.003
[Indexed for MEDLINE]
Free PMC Article

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