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J Gen Virol. 1989 Dec;70 ( Pt 12):3147-57.

Gene UL11 of herpes simplex virus type 1 encodes a virion protein which is myristylated.

Author information

1
MRC Virology Unit, University of Glasgow, U.K.

Abstract

We have investigated whether herpes simplex virus (HSV) contains structural polypeptides which are modified by myristic acid. We demonstrate that herpes simplex virions contain a family of myristylated proteins, Mr approximately 13,000 to 16,000. These were mapped, using HSV-1/HSV-2 intertypic recombinants, to 0.130 to 0.204 map units on the virus genome. Using anti-peptide sera, raised against the carboxyterminus of the predicted UL11 gene product, we have established that the myristylated virion polypeptides are products of the viral gene UL11.

PMID:
2558153
DOI:
10.1099/0022-1317-70-12-3147
[Indexed for MEDLINE]

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