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Nat Genet. 2015 Feb;47(2):164-71. doi: 10.1038/ng.3185. Epub 2015 Jan 12.

Identification of six new susceptibility loci for invasive epithelial ovarian cancer.

Kuchenbaecker KB, Ramus SJ, Tyrer J, Lee A, Shen HC, Beesley J, Lawrenson K, McGuffog L, Healey S, Lee JM, Spindler TJ, Lin YG, Pejovic T, Bean Y, Li Q, Coetzee S, Hazelett D, Miron A, Southey M, Terry MB, Goldgar DE, Buys SS, Janavicius R, Dorfling CM, van Rensburg EJ, Neuhausen SL, Ding YC, Hansen TV, Jønson L, Gerdes AM, Ejlertsen B, Barrowdale D, Dennis J, Benitez J, Osorio A, Garcia MJ, Komenaka I, Weitzel JN, Ganschow P, Peterlongo P, Bernard L, Viel A, Bonanni B, Peissel B, Manoukian S, Radice P, Papi L, Ottini L, Fostira F, Konstantopoulou I, Garber J, Frost D, Perkins J, Platte R, Ellis S; EMBRACE, Godwin AK, Schmutzler RK, Meindl A, Engel C, Sutter C, Sinilnikova OM; GEMO Study Collaborators, Damiola F, Mazoyer S, Stoppa-Lyonnet D, Claes K, De Leeneer K, Kirk J, Rodriguez GC, Piedmonte M, O'Malley DM, de la Hoya M, Caldes T, Aittomäki K, Nevanlinna H, Collée JM, Rookus MA, Oosterwijk JC; Breast Cancer Family Registry, Tihomirova L, Tung N, Hamann U, Isaccs C, Tischkowitz M, Imyanitov EN, Caligo MA, Campbell IG, Hogervorst FB; HEBON, Olah E, Diez O, Blanco I, Brunet J, Lazaro C, Pujana MA, Jakubowska A, Gronwald J, Lubinski J, Sukiennicki G, Barkardottir RB, Plante M, Simard J, Soucy P, Montagna M, Tognazzo S, Teixeira MR; KConFab Investigators, Pankratz VS, Wang X, Lindor N, Szabo CI, Kauff N, Vijai J, Aghajanian CA, Pfeiler G, Berger A, Singer CF, Tea MK, Phelan CM, Greene MH, Mai PL, Rennert G, Mulligan AM, Tchatchou S, Andrulis IL, Glendon G, Toland AE, Jensen UB, Kruse TA, Thomassen M, Bojesen A, Zidan J, Friedman E, Laitman Y, Soller M, Liljegren A, Arver B, Einbeigi Z, Stenmark-Askmalm M, Olopade OI, Nussbaum RL, Rebbeck TR, Nathanson KL, Domchek SM, Lu KH, Karlan BY, Walsh C, Lester J; Australian Cancer Study (Ovarian Cancer Investigators); Australian Ovarian Cancer Study Group, Hein A, Ekici AB, Beckmann MW, Fasching PA, Lambrechts D, Van Nieuwenhuysen E, Vergote I, Lambrechts S, Dicks E, Doherty JA, Wicklund KG, Rossing MA, Rudolph A, Chang-Claude J, Wang-Gohrke S, Eilber U, Moysich KB, Odunsi K, Sucheston L, Lele S, Wilkens LR, Goodman MT, Thompson PJ, Shvetsov YB, Runnebaum IB, Dürst M, Hillemanns P, Dörk T, Antonenkova N, Bogdanova N, Leminen A, Pelttari LM, Butzow R, Modugno F, Kelley JL, Edwards RP, Ness RB, du Bois A, Heitz F, Schwaab I, Harter P, Matsuo K, Hosono S, Orsulic S, Jensen A, Kjaer SK, Hogdall E, Hasmad HN, Azmi MA, Teo SH, Woo YL, Fridley BL, Goode EL, Cunningham JM, Vierkant RA, Bruinsma F, Giles GG, Liang D, Hildebrandt MA, Wu X, Levine DA, Bisogna M, Berchuck A, Iversen ES, Schildkraut JM, Concannon P, Weber RP, Cramer DW, Terry KL, Poole EM, Tworoger SS, Bandera EV, Orlow I, Olson SH, Krakstad C, Salvesen HB, Tangen IL, Bjorge L, van Altena AM, Aben KK, Kiemeney LA, Massuger LF, Kellar M, Brooks-Wilson A, Kelemen LE, Cook LS, Le ND, Cybulski C, Yang H, Lissowska J, Brinton LA, Wentzensen N, Hogdall C, Lundvall L, Nedergaard L, Baker H, Song H, Eccles D, McNeish I, Paul J, Carty K, Siddiqui N, Glasspool R, Whittemore AS, Rothstein JH, McGuire V, Sieh W, Ji BT, Zheng W, Shu XO, Gao YT, Rosen B, Risch HA, McLaughlin JR, Narod SA, Monteiro AN, Chen A, Lin HY, Permuth-Wey J, Sellers TA, Tsai YY, Chen Z, Ziogas A, Anton-Culver H, Gentry-Maharaj A, Menon U, Harrington P, Lee AW, Wu AH, Pearce CL, Coetzee G, Pike MC, Dansonka-Mieszkowska A, Timorek A, Rzepecka IK, Kupryjanczyk J, Freedman M, Noushmehr H, Easton DF, Offit K, Couch FJ, Gayther S, Pharoah PP, Antoniou AC, Chenevix-Trench G; Consortium of Investigators of Modifiers of BRCA1 and BRCA2.

Collaborators (1269)

Green AC, Parsons PG, Hayward NK, Purdie DM, Webb PM, Whiteman DC, Bowtell D, Chenevix-Trench G, Green A, Webb P, deFazio A, Gertig D, Hopper JL, Miron A, Goldgar DE, John EM, Terry MB, Whittemore AS, Buys SS, Chung WK, Daly MB, Southey M, Miron A, John EM, Hopper JL, Southey M, Whittemore AS, Terry MB, Chung WK, Daly MB, Goldgar DE, Buys SS, Janavicius R, Rudaitis V, Eglitis J, Tihomirova L, Nikitina-Zake L, Tung N, Dorfling CM, van Rensburg EJ, Steele L, Neuhausen SL, Ding YC, Gerdes AM, Ejlertsen B, Nielsen FC, Jønson L, Andersen MK, Hansen TV, Lee A, Antoniou AC, Barrowdale D, Dennis J, Kuchenbaecker KB, McGuffog L, Healey S, Easton DF, Chenevix-Trench G, Lee A, Wang C, Cunningham J, Hart S, Slager S, Lasa A, Osorio A, Benitez J, Godino J, Tejada MI, Garcia MJ, Duran M, Hall P, Dicks E, Fontaine A, Komenaka I, Weitzel JN, Herzog J, Ganschow P, Peterlongo P, Pilato B, Lambo R, Tommasi S, Sardella D, Capra F, Ficarazzi F, Mariette F, Tizzoni L, Bernard L, Mariani P, Volorio S, Fortuzzi S, Dall'Olio V, Pensotti V, Viel A, Dolcetti R, Bonanni B, Feroce I, Barile M, Peissel B, Zaffaroni D, Cattaneo E, Roversi G, Melloni G, Scuvera G, Radice P, Manoukian S, Martayan A, Savarese A, Varesco L, Gismondi V, Putignano AL, Papi L, Genuardi M, Tibiletti MG, Ottini L, Allavena A, Pasini B, Vignolo-Lutati F, Vratimos A, Fostira F, Fountzilas G, Konstantopoulou I, Apostolou P, Garber J, Torres D, Rashid MU, Hamann U, Donaldson A, Murray A, Dunning AM, Chu C, Brewer C, Houghton C, Jacobs C, Oliver C, Evans DG, Frost D, Eccles D, Fineberg E, Easton DF, Frost D, Ellis S, Platte R, Perkins J, Miedzybrodzka Z, Gregory H, Morrison P, Jeffers L, Ong KR, Hoffman J, Donaldson A, James M, Paterson J, Tischkowitz M, Downing S, Taylor A, Murray A, Rogers MT, McCann E, Kennedy MJ, Barton D, Porteous M, Drummond S, Brewer C, Kivuva E, Searle A, Goodman S, Hill K, Davidson R, Murday V, Bradshaw N, Snadden L, Longmuir M, Watt C, Gibson S, Haque E, Tobias E, Duncan A, Izatt L, Jacobs C, Langman C, Dorkins H, Barwell J, Adlard J, Serra-Feliu G, Ellis I, Foo C, Evans DG, Lalloo F, Taylor J, Side L, Male A, Berlin C, Eason J, Collier R, Henderson A, Claber O, Jobson I, Walker L, McLeod D, Halliday D, Durell S, Stayner B, Eeles R, Rahman N, Bancroft E, Page E, Ardern-Jones A, Kohut K, Wiggins J, Pope J, Saya S, Taylor N, Kemp Z, Cook J, Quarrell O, Bardsley C, Hodgson S, Goff S, Brice G, Winchester L, Eddy C, Tripathi V, Attard V, Eccles D, Lucassen A, Crawford G, McBride D, Smalley S, McCann E, Douglas F, Lalloo F, ichert G, Gregory H, Dorkins H, Cook J, Eason J, Perkins J, Paterson J, Adlard J, Barwell J, Ong KR, Walker L, Izatt L, Side LE, Kennedy MJ, Cook M, Rogers MT, Porteous ME, Harrington P, Morrison PJ, Platte R, Eeles R, Davidson R, Hodgson S, Ellis S, Peock S, Cole T, Godwin AK, Bove B, Weaver J, Sharma P, Lee A, Shapira I, Vega A, Becker A, Meindl A, Gehrig A, Baumgärtner A, Wappenschmidt B, Weber BH, Sutter C, Engel C, Niederacher D, Schäfer D, Steinemann D, Gadzicki D, Hahnen E, Plendl H, Deissler H, Ruehl I, Kast K, Rhiem K, Ditsch N, Arnold N, Varon-Mateeva R, Schmutzler RK, Preisler-Adams S, Heidemann S, Engert S, Heinritz W, Hardouin A, Calender A, de Pauw A, Bressac-de Paillerets B, Buecher B, Delnatte C, Tirapo C, Verny-Pierre C, Kientz C, Nogues C, Lasset C, Houdayer C, Muller D, Leroux D, Stoppa-Lyonnet D, Rouleau E, Lesueur F, Prieur F, Damiola F, Sinilnikova O, Mazoyer S, Damiola F, Barjhoux L, Verny-Pierre C, Giraud S, Léone M, Boutry-Kryza N, Stoppa-Lyonnet D, Gauthier-Villars M, Buecher B, Houdayer C, Rouleau E, Golmard L, Collet A, Moncoutier V, Lefol C, Belotti M, de Pauw A, Elan C, Nogues C, Fourme E, Birot AM, Bressac-de-Paillerets B, Caron O, Guillaud-Bataille M, Bignon YJ, Uhrhammer N, Lasset C, Bonadona V, Handallou S, Hardouin A, Berthet P, Vaur D, Castera L, Sobol H, Bourdon V, Noguchi T, Remenieras A, Eisinger F, Coupier I, Pujol P, Peyrat JP, Fournier J, Révillion F, Vennin P, Adenis C, Muller D, Fricker JP, Barouk-Simonet E, Bonnet F, Bubien V, Sevenet N, Longy M, Toulas C, Guimbaud R, Gladieff L, Feillel V, Leroux D, Dreyfus H, Rebischung C, Peysselon M, Coron F, Faivre L, Prieur F, Lebrun M, Kientz C, Ferrer SF, Frénay M, Vénat-Bouvet L, Delnatte C, Mortemousque I, Coulet F, Colas C, Soubrier F, Warcoin M, Sokolowska J, Bronner M, Lynch HT, Snyder CL, Sobol H, Dreyfus H, Coupier I, Peyrat JP, Fricker JP, Sokolowska J, Barjhoux L, Faivre L, Venat-Bouvet L, Castera L, Akloul L, Golmard L, Frenay M, Collonge-Rame MA, Remon MA, Lebrun M, Fassy-Colcombet M, Gauthier-Villars M, Léoné M, Longy M, Belotti M, Bronner M, Boutry-Kryza N, Uhrhammer N, Sevenet N, Sinilnikova OM, Caron O, Pujol P, Berthet P, Ferrer SF, Giraud S, Mazoyer S, Bonadona V, Caux-Moncoutier V, Bignon YJ, Isaacs C, De Paepe A, Poppe B, Claes K, De Leeneer K, Cohn DE, O'Malley DM, Rodriguez GC, Basil JB, Hoffman JS, Fiorica JV, Hurteau JA, Boggess JF, Byron JW, Carter J, Kirk J, Wakeley K, Phillips KA, Small L, Andrews L, DeMars LR, Van Le L, Piedmonte M, Azodi M, Friedlander M, DiSilvestro PA, Schwartz PE, Salani R, Nerenstone SR, Blank SV, Bae-Jump VL, Romero A, de la Hoya M, Segura PP, Caldes T, Nevanlinna H, Aittomäki K, Khan S, Muranen TA, Jager A, van der Hout AH, van den Ouweland AM, Hollestelle A, Mensenkamp AR, van Deurzen CH, Kets CM, Seynaeve C, van Asperen CJ, Aalfs CM, Garcia EB, van Leeuwen FE, Hogervorst FB, van der Baan FH, Meijers-Heijboer HE, Vasen HF, Rookus MA, Hogervorst FB, van Leeuwen FE, Verhoef S, Schmidt MK, Russell NS, de Lange JL, Wijnands R, Collée JM, van den Ouweland AM, Hooning MJ, Seynaeve C, van Deurzen CH, Obdeijn IM, van Asperen CJ, Wijnen JT, Tollenaar RA, Devilee P, van Cronenburg TC, Kets CM, Mensenkamp AR, Ausems MG, van der Luijt RB, van der Pol CC, Aalfs CM, van Os TA, Gille JJ, Waisfisz Q, Meijers-Heijboer HE, Gómez-Garcia EB, Blok MJ, Vasen HF, Siesling S, Verloop J, Overbeek LI, Kluijt I, Collee J, Gille JJ, Knol-Bout JP, Oosterwijk JC, Wijnen JT, van Roozendaal KE, Schrijver LH, Hooning MJ, Tilanus-Linthorst MA, Ausems MG, Blom MJ, van Dooren MF, Blok MJ, Ligtenberg MJ, Rookus MA, Kriege M, Hoogerbrugge N, Devilee P, Waisfisz Q, van der Luijt RB, Verhoef S, van Os TA, Kwong A, Ma E, Chan TL, Olah E, Papp J, Vaszko T, Pocza T, Balmana J, Bosch N, Diez O, Teule A, Izquierdo A, Velasco A, Solanes A, Lazaro C, Darder E, Tornero E, Capella G, Blanco I, Del Valle J, Brunet J, Feliubadalo L, Navarro M, Pujana MA, Menendez M, Salinas M, Iglesias S, Toloczko-Grabarek A, Jakubowska A, Gorski B, Cybulski C, Złowocka-Perłowska E, Sukiennicki G, Gronwald J, Lubinski J, Menkiszak J, Durda K, Jaworska-Bieniek K, bniak TD, Byrski T, Huzarski T, Arason A, Agnarsson BA, Johannsson OT, Barkardottir RB, Lesperance B, Maugard C, Chiquette J, Plante M, Dumont M, Laframboise R, Simard J, Soucy P, Casella C, Alducci E, D'Andrea E, Montagna M, Tognazzo S, Agata S, Peixoto A, Teixeira MR, Spurdle AB, Holland H, Beesley J, Aghmesheh M, Amor D, Andrews L, Antill Y, Armitage S, Arnold L, Balleine R, Bankier A, Bastick P, Beesley J, Beilby J, Bennett B, Bennett I, Berry G, Blackburn A, Bogwitz M, Brennan M, Brown M, Buckley M, Burgess M, Burke J, Butow P, Byron K, Callen D, Campbell I, Chauhan D, Chauhan M, Chenevix-Trench G, Christian A, Clarke C, Colley A, Cotton D, Crook A, Cui J, Culling B, Cummings M, Dawson SJ, deFazio A, Delatycki M, Dickson R, Dixon J, Dobrovic A, Dudding T, Edkins T, Edwards S, Eisenbruch M, Farshid G, Fawcett S, Fellows A, Fenton G, Field M, Firgaira F, Flanagan J, Fleming J, Fong P, Forbes J, Fox S, French J, Friedlander M, Gaff C, Gardner M, Gattas M, George P, Giles G, Gill G, Goldblatt J, Greening S, Grist S, Haan E, Hardie K, Harris M, Hart S, Hayward N, Healey S, Heiniger L, Hopper J, Humphrey E, Hunt C, James P, Jenkins M, Jones A, Kefford R, Kidd A, Kiely B, Kirk J, Koehler J, Kollias J, Kovalenko S, Lakhani S, Leaming A, Leary J, Lim J, Lindeman G, Lipton L, Lobb L, Mann G, Marsh D, McLachlan SA, Meiser B, Meldrum C, Milne R, Mitchell G, Newman B, Niedermayr E, Nightingale S, O'Connell S, O'Loughlin I, Osborne R, Pachter N, Patterson B, Peters L, Phillips K, Price M, Purser L, Reeve T, Reeve J, Richards R, Rickard E, Rudzki BR, Saleh M, Salisbury E, Sambrook J, Saunders C, Saunus J, Sayer R, Scott E, Scott R, Scott C, Seshadri R, Sexton A, Sharma R, Shelling A, Simpson P, Southey M, Spurdle A, Suthers G, Sykes P, Tassell M, Taylor D, Taylor J, Thierry B, Thomas S, Thompson E, Thorne H, Townshend S, Trainer A, Tran L, Tucker K, Visvader JT, Walker L, Walpole I, Ward R, Waring P, Warner B, Warren G, Williams R, Wilson J, Winship I, Wu K, Young MA, Chen X, Lee JW, Lee MH, Park SK, Kim SW, Friebel T, Olswold C, Stevens K, Kosel M, Lindor N, Pankratz VS, Wang X, Fredericksen Z, Couch FJ, Tischkowitz M, Foulkes WD, Szabo CI, Machackova E, Foretova L, Zikan M, Pohlreich P, Kleibl Z, Catts ZA, Dutra-Clarke A, Aghajanian CA, Przybylo J, Vijai J, Sarrel K, Offit K, Corines M, Robson M, Gaudet MM, Kauff N, Shah S, Kirchhoff T, Berger A, Fink-Retter A, Singer CF, Rappaport C, Kaulich DG, Pfeiler G, Tea MK, Phelan CM, Narod SA, Greene MH, Mai PL, Savage SA, Loud JT, Sherman ME, Lejbkowicz F, Rennert G, Sokolenko AP, Imyanitov EN, Selkirk C, Hulick P, Mulligan AM, Glendon G, Ozcelik H, Andrulis IL, Tchatchou S, Toland AE, Senter L, Bojesen A, Skytte AB, Pedersen IS, Sunde L, Thomassen M, Moeller ST, Væth S, Kruse TA, Jensen UB, Collavoli A, Caligo MA, Tancredi M, Aretini P, Teo SH, Kaufman B, Friedman E, Zidan J, Berger R, Laitman Y, Borg A, Öfverholm A, von Wachenfeldt A, Liljegren A, Lindblom A, Melin B, Arver B, Ardnor CE, Bustinza GB, Olsson H, Ehrencrona H, Jernström H, Rantala J, Henriksson K, Harbst K, Nordling M, Soller M, Stenmark-Askmalm M, Pigg MH, Emanuelsson M, Loman N, Karlsson P, Rosenquist R, Liedgren S, Kristoffersson U, Einbeigi Z, Huo D, Sighoko D, Zhang J, Patrick-Miller L, Verp M, Olopade OI, Nielsen S, Zheng Y, Seldon J, Ganz PA, Nussbaum RL, Chan SB, Moysich KB, Odunsi K, Sucheston L, Pharoah PD, Gayther SA, Ramus SJ, Nathanson KL, Domchek SM, Rebbeck TR, Arun BK, Lu KH, Mitchell G, Campbell I, James P, Karlan BY, Walsh C, Lester J, Orsulic S, Easton DF, Frost D, Ellis S, Platte R, Perkins J, Miedzybrodzka Z, Gregory H, Morrison P, Jeffers L, Kai-ren Ong, Hoffman J, Donaldson A, James M, Paterson J, Tischkowitz M, Downing S, Taylor A, Murray A, Rogers MT, McCann E, Kennedy M, Barton D, Porteous M, Drummond S, Brewer C, Kivuva E, Searle A, Goodman S, Hill K, Davidson R, Murday V, Bradshaw N, Snadden L, Longmuir M, Watt C, Gibson S, Haque E, Tobias E, Duncan A, Izatt L, Jacobs C, Langman C, Dorkins H, Barwell J, Adlard J, Serra-Feliu G, Ellis I, Foo C, Evans DG, Lalloo F, Taylor J, Thames NE, Side L, Male A, Berlin C, Eason J, Collier R, Henderson A, Claber O, Jobson I, Walker L, McLeod D, Halliday D, Durell S, Stayner B, Eeles R, Rahman N, Bancroft E, Page E, Ardern-Jones A, Kohut K, Wiggins J, Pope J, Saya S, Taylor N, Kemp Z, George A, Cook J, Quarrell O, Bardsley C, Hodgson S, Goff S, Brice G, Winchester L, Eddy C, Tripathi V, Attard V, Eccles D, Lucassen A, Crawford G, McBride D, Smalley S, Sinilnikova O, Mazoyer S, Damiola F, Barjhoux L, Verny-Pierre C, Giraud S, Léone M, Boutry-Kryza N, Stoppa-Lyonnet D, Gauthier-Villars M, Buecher B, Houdayer C, Rouleau E, Golmard L, Collet A, Moncoutier V, Lefol C, Belotti M, de Pauw A, Elan C, Nogues C, Fourme E, Birot AM, Bressac-dePaillerets B, Caron O, Guillaud-Bataille M, Bignon YJ, Uhrhammer N, Lasset C, Bonadona V, Handallou S, Hardouin A, Berthet P, Vaur D, Castera L, Sobol H, Bourdon V, Noguchi T, Remenieras A, Eisinger F, Coupier I, Pujol P, Fournier JP, Révillion F, Vennin P, Adenis C, Muller D, Fricker JP, Barouk-Simonet E, Bonnet F, Bubien V, Sevenet N, Longy M, Toulas C, Guimbaud R, Gladieff L, Feillel V, Leroux D, Dreyfus H, Rebischung C, Peysselon M, Coron F, Faivre L, Prieur F, Lebrun M, Kientz C, Ferrer SF, Frénay M, Vénat-Bouvet L, Delnatte C, Mortemousque I, Coulet F, Colas C, Soubrier F, Warcoin M, Sokolowska J, Bronner M, Lynch HT, Snyder CL, Rookus MA, Hogervorst FB, van Leeuwen FE, Verhoef S, Schmidt MK, Russell NS, de Lange JL, Wijnands R, van den Ouweland AM, Hooning MJ, Seynaeve C, van Deurzen CH, Obdeijn IM, van Asperen CJ, Wijnen JT, Tollenaar RA, Devilee P, van Cronenburg TC, Kets CM, Mensenkamp AR, Ausems MG, van der Luijt RB, van der Pol CC, Aalfs CM, van Os TA, Gille JJ, Waisfisz Q, Meijers-Heijboer HE, Gómez-Garcia EB, Blok MJ, Oosterwijk JC, van der Hout AH, Mourits MJ, de Bock GH, Vasen HF, Siesling S, Verloop J, Overbeek LI, Aghmesheh M, Amor D, Andrews L, Antill Y, Armitage S, Arnold L, Balleine R, Bankier A, Bastick P, Beesley J, Beilby J, Bennett B, Bennett I, Berry G, Blackburn A, Bogwitz M, Brennan M, Brown M, Buckley M, Burgess M, Burke J, Butow P, Byron K, Callen D, Campbell I, Chauhan D, Chauhan M, Chenevix-Trench G, Christian A, Clarke C, Colley A, Cotton D, Crook A, Cui J, Culling B, Cummings M, Dawson SJ, deFazio A, Delatycki M, Dickson R, Dixon J, Dobrovic A, Dudding T, Edkins T, Edwards S, Eisenbruch M, Farshid G, Fawcett S, Fellows A, Fenton G, Field M, Firgaira F, Flanagan J, Fleming J, Fong P, Forbes J, Fox S, French J, Friedlander M, Gaff C, Gardner M, Gattas M, George P, Giles G, Gill G, Goldblatt J, Greening S, Grist S, Haan E, Hardie K, Harris M, Hart S, Hayward N, Healey S, Heiniger L, Hopper J, Humphrey E, Hunt C, James P, Jenkins M, Jones A, Kefford R, Kidd A, Kiely B, Kirk J, Koehler J, Kollias J, Kovalenko S, Lakhani S, Leaming A, Leary J, Lim J, Lindeman G, Lipton L, Lobb L, Mann G, Marsh D, McLachlan SA, Meiser B, Meldrum C, Milne R, Mitchell G, Newman B, Niedermayr E, Nightingale S, O'Connell S, O'Loughlin I, Osborne R, Pachter N, Patterson B, Peters L, Phillips K, Price M, Purser L, Reeve T, Reeve J, Richards R, Rickard E, Robinson B, Rudzki B, Saleh M, Salisbury E, Sambrook J, Saunders C, Saunus J, Sayer R, Scott E, Scott R, Scott C, Seshadri R, Sexton A, Sharma R, Shelling A, Simpson P, Southey M, Spurdle A, Suthers G, Sykes P, Tassell M, Taylor D, Taylor J, Thierry B, Thomas S, Thompson E, Thorne H, Townshend S, Trainer A, Tran L, Tucker K, Tyler J, Visvader J, Walker L, Walpole I, Ward R, Waring P, Warner B, Warren G, Williams R, Wilson J, Winship I, Wu K, Young MA.

Abstract

Genome-wide association studies (GWAS) have identified 12 epithelial ovarian cancer (EOC) susceptibility alleles. The pattern of association at these loci is consistent in BRCA1 and BRCA2 mutation carriers who are at high risk of EOC. After imputation to 1000 Genomes Project data, we assessed associations of 11 million genetic variants with EOC risk from 15,437 cases unselected for family history and 30,845 controls and from 15,252 BRCA1 mutation carriers and 8,211 BRCA2 mutation carriers (3,096 with ovarian cancer), and we combined the results in a meta-analysis. This new study design yielded increased statistical power, leading to the discovery of six new EOC susceptibility loci. Variants at 1p36 (nearest gene, WNT4), 4q26 (SYNPO2), 9q34.2 (ABO) and 17q11.2 (ATAD5) were associated with EOC risk, and at 1p34.3 (RSPO1) and 6p22.1 (GPX6) variants were specifically associated with the serous EOC subtype, all with P < 5 × 10(-8). Incorporating these variants into risk assessment tools will improve clinical risk predictions for BRCA1 and BRCA2 mutation carriers.

PMID:
25581431
PMCID:
PMC4445140
DOI:
10.1038/ng.3185
[Indexed for MEDLINE]
Free PMC Article

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