Format

Send to

Choose Destination
Cytopathology. 2016 Apr;27(2):83-90. doi: 10.1111/cyt.12230. Epub 2015 Jan 12.

Cytomorphological characteristics of low-grade papillary urothelial carcinoma for differential diagnosis from benign papillary urothelial lesions: logistic regression analysis in SurePath(™) liquid-based voided urine cytology.

Author information

1
Department of Pathology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
2
Department of Pathology, Cancer Center, Dongnam Institute of Radiological and Medical Sciences (DIRAMS), Busan, South Korea.

Abstract

OBJECTIVE:

The diagnosis of low-grade papillary urothelial carcinoma (LGPUC) in urine cytology specimens is challenging because of its subtle, minimally atypical findings. Furthermore, as SurePath(™) liquid-based cytology (LBC) is becoming a widely used method in urine cytology, the inevitable cytomorphological alterations resulting from this technique call for new morphological diagnostic criteria in LGPUC.

METHODS:

Logistic regression analysis was carried out on SurePath slides from surgically proven voided urine specimens. The study was designed to include a test set (n = 141) and a validation set (n = 61), and evaluated significant discriminative parameters between LGPUC and benign papillary urothelial neoplasm (BPUN).

RESULTS:

Of the seven cytological findings that were found to have statistical significance in univariate analysis, five were found to be independent variables: loss of polarity of papillaroid clusters, irregular contours, absence of columnar cells, hobnail features and hyperchromasia. These independent variables had an area under the curve (AUC) of 0.781.

CONCLUSIONS:

The distinctive cytological criteria identified above may prove to be helpful in cases in which other conventional criteria for LGPUC are insufficient for diagnosis.

KEYWORDS:

SurePath™; benign papillary urothelial neoplasm; liquid-based cytology; logistic regression analysis; low-grade papillary urothelial carcinoma; urine cytology

PMID:
25580773
DOI:
10.1111/cyt.12230
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center