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ScientificWorldJournal. 2014;2014:953181. doi: 10.1155/2014/953181. Epub 2014 Dec 15.

Screening of trace elements in hair of the female population with different types of cancers in Wielkopolska region of Poland.

Author information

1
Department of General Pharmacology and Pharmacoeconomics, Pomeranian Medical University in Szczecin, Zolnierska 48, 70-204 Szczecin, Poland ; Department of Pharmacology and Phytochemistry, Institute of Natural Fibers and Medicinal Plants, Wojska Polskiego 71b, 60-630 Poznan, Poland.
2
Department of General Pharmacology and Pharmacoeconomics, Pomeranian Medical University in Szczecin, Zolnierska 48, 70-204 Szczecin, Poland.
3
Department of Pharmacology and Phytochemistry, Institute of Natural Fibers and Medicinal Plants, Wojska Polskiego 71b, 60-630 Poznan, Poland ; Department of Pharmaceutical Botany and Plant Biotechnology, Poznan University of Medical Sciences, Święty Marii Magdaleny 14, 61-861 Poznan, Poland.
4
Department of Pharmacology and Phytochemistry, Institute of Natural Fibers and Medicinal Plants, Wojska Polskiego 71b, 60-630 Poznan, Poland ; Division of Perinatology and Women's Diseases, Poznan University of Medical Sciences, Polna 33, 60-535 Poznan, Poland ; Laboratory of Molecular Biology, Poznan University of Medical Sciences, Polna 33, 60-535 Poznan, Poland.

Abstract

BACKGROUND:

Cancer constitutes a major health problem worldwide. Thus, search for reliable and practical markers of the disease process remains the key issue of the diagnostic process.

OBJECTIVES:

The study aims at linking the trace element status of an organism, assessed by hair analysis, with the occurrence of cancer diseases.

MATERIAL AND METHODS:

Hair samples were collected from 299 patients with cancer diseases confirmed by a histopathological test and from 100 controls. Cancer patients were divided into three groups, depending on cancer type: hormone-dependent cancer, cancer of the alimentary tract, and cancer with high glycolytic activity. Mineral element analysis of hair was performed using an atomic emission spectrophotometer with inductively coupled plasma (ICP-OES) and inductively coupled plasma mass spectrometry (ICP-MS).

RESULTS:

Statistically significantly lower concentrations of selenium, zinc, copper, germanium and boron, iron, and magnesium were observed in the three groups of cancer patients. Disturbance in the axis glucose-insulin and changes in concentrations of heavy metals and toxic elements were also noted.

CONCLUSIONS:

It seems safe to conclude that our results confirmed usefulness of hair element analysis in screening tests for the assessment of the biomarker of various cancer diseases in a female population.

PMID:
25580464
PMCID:
PMC4279272
DOI:
10.1155/2014/953181
[Indexed for MEDLINE]
Free PMC Article

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