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Eur J Pharmacol. 1989 Sep 13;168(2):239-42.

NMDA receptor blockade in the periaqueductal grey prevents stress-induced analgesia in attacked mice.

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1
Institute of Pharmacology, University of Zurich, Switzerland.

Abstract

Microinjections of N-methyl-D-aspartate (NMDA, 0.1 and 1.0 nmol) into the periaqueductal grey (PAG) of the mouse resulted in potential antinociception. In a social conflict situation, attacked mice exhibited a marked analgesia that was prevented by prior injection of the competitive NMDA antagonist, AP-7 (2.0 nmol) or naloxone (6.0 nmol) into the PAG and also by i.p. injection of the non-competitive NMDA antagonist, MK-801 (33 nmol). These results demonstrate that NMDA receptors are involved in endogenous analgesic mechanisms activated by stress.

PMID:
2558025
[Indexed for MEDLINE]
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