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Bull Hosp Jt Dis Orthop Inst. 1989 Fall;49(2):192-204.

The effect of aluminum and gallium ions on the mineralization process.

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Department of Bioengineering, Hospital for Joint Diseases Orthopaedic Institute, New York, NY 10003.


Metal ions have various and significant effects on the skeletal system. Aluminum accumulation in renal dialysis patients causes osteomalacia, while gallium is an effective therapeutic agent for treating the hypercalcemia accompanying certain malignancies. Using in-vitro systems that stimulate in-vivo mineralization, the authors have investigated the physical-chemical mechanisms of the actions of aluminum and gallium and report some of their findings.

[Indexed for MEDLINE]

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