Format

Send to

Choose Destination
Brain Lang. 2015 Feb;141:103-9. doi: 10.1016/j.bandl.2014.12.004. Epub 2015 Jan 8.

The effects of subthalamic deep brain stimulation on metaphor comprehension and language abilities in Parkinson's disease.

Author information

1
Faculté de médecine, Département de réadaptation, Université Laval, 1050, ave de la Médecine, Québec, QC G1V 0A6, Canada; Institut Universitaire en Santé Mentale de Québec, 2601, rue de la Canardière, Québec, QC G1J 2G3, Canada. Electronic address: christina.tremblay.1@ulaval.ca.
2
Faculté de médecine, Département de réadaptation, Université Laval, 1050, ave de la Médecine, Québec, QC G1V 0A6, Canada; Institut Universitaire en Santé Mentale de Québec, 2601, rue de la Canardière, Québec, QC G1J 2G3, Canada. Electronic address: Joel.Macoir@rea.ulaval.ca.
3
Clinique des troubles du mouvement, Hôpital de l'Enfant-Jésus, 1401, 18(e) rue, Québec, QC G1J 1Z4, Canada. Electronic address: Melanie.Langlois.cha@ssss.gouv.qc.ca.
4
Clinique des troubles du mouvement, Hôpital de l'Enfant-Jésus, 1401, 18(e) rue, Québec, QC G1J 1Z4, Canada. Electronic address: leo.cantin.cha@ssss.gouv.qc.ca.
5
Clinique des troubles du mouvement, Hôpital de l'Enfant-Jésus, 1401, 18(e) rue, Québec, QC G1J 1Z4, Canada. Electronic address: michel.prudhomme.chuq@gmail.com.
6
Faculté de médecine, Département de réadaptation, Université Laval, 1050, ave de la Médecine, Québec, QC G1V 0A6, Canada; Institut Universitaire en Santé Mentale de Québec, 2601, rue de la Canardière, Québec, QC G1J 2G3, Canada. Electronic address: laura.monetta@rea.ulaval.ca.

Abstract

The effects of subthalamic nucleus (STN) deep brain stimulation (DBS) in Parkinson's disease (PD) on different language abilities are still controversial and its impact on high-level language abilities such as metaphor comprehension has been overlooked. The aim of this study was to determine the effects of STN electrical stimulation on metaphor comprehension and language abilities such as lexical and semantic capacities. Eight PD individuals with bilateral STN-DBS were first evaluated OFF-DBS and, at least seven weeks later, ON-DBS. Performance on metaphor comprehension, lexical decision, word association and verbal fluency tasks were compared ON and OFF-DBS in addition to motor symptoms evaluation. STN stimulation had a significant beneficial effect on motor symptoms in PD. However, this stimulation did not have any effect on metaphor comprehension or any other cognitive ability evaluated in this study. These outcomes suggest that STN stimulation may have dissociable effects on motor and language functions.

KEYWORDS:

Deep brain stimulation; Language; Metaphor comprehension; Parkinson’s disease

PMID:
25577507
DOI:
10.1016/j.bandl.2014.12.004
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center