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Food Chem. 2015 May 15;175:409-16. doi: 10.1016/j.foodchem.2014.11.122. Epub 2014 Nov 28.

Screening antimutagenic and antiproliferative properties of extracts isolated from Jackfruit pulp (Artocarpus heterophyllus Lam).

Author information

1
Laboratorio Integral de Investigación en Alimentos, Instituto Tecnológico de Tepic, Av. Tecnológico 2595, C.P. 63175 Tepic, Nayarit, Mexico.
2
Departamento de Investigación y Posgrado en Alimentos, Universidad de Sonora, C.P. 8300 Hermosillo, Sonora, Mexico.
3
Laboratorio Integral de Investigación en Alimentos, Instituto Tecnológico de Tepic, Av. Tecnológico 2595, C.P. 63175 Tepic, Nayarit, Mexico. Electronic address: montserratcalder@gmail.com.
4
Departamento de Ciencias Químico-Biológicas, Universidad de Sonora, C.P. 1658 Hermosillo, Sonora, Mexico.
5
Universidad Nacional Autónoma de México, Facultad de Química, Circuito Interior, Ciudad Universitaria, Col. Copilco, C.P. 04510 Coyoacán, D.F., Mexico.
6
Laboratorio Integral de Investigación en Alimentos, Instituto Tecnológico de Tepic, Av. Tecnológico 2595, C.P. 63175 Tepic, Nayarit, Mexico. Electronic address: arturoragazzo@hotmail.com.

Abstract

The present focused on the study of the antimutagenic and antiproliferative potential of pulp Jackfruit (Artocarpus heterophyllus Lam) extract, using Salmonella typhimurium tester strains TA98 and TA100 with metabolic activation (S9) and a cancer cell line M12.C3.F6 (murine B-cell lymphoma), respectively. Jackfruit pulp extract was sequentially fractionated by chromatography (RP-HPLC) and each fraction was tested for antimutagenic and antiproliferative activities. The organic extracts obtained from Jackfruit pulp reduced the number of revertants caused by aflatoxin B1 (AFB1) and proliferation of cells M12.C3.F6; a dose-response relationship was showed. Sequential RP-HPLC fractionation of the active extracts produced both antimutagenic and/or antiproliferative fractions. These results suggested that the Jackfruit contained compounds with chemoprotective properties to reduce the mutagenicity of AFB1, also proliferation of a cancer cell line.

KEYWORDS:

Antimutagenic; Antioxidant; Antiproliferative; Chemoprotective properties; Jackfruit pulp; RP-HPLC

PMID:
25577099
DOI:
10.1016/j.foodchem.2014.11.122
[Indexed for MEDLINE]

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