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Curr Opin Microbiol. 2015 Feb;23:141-7. doi: 10.1016/j.mib.2014.11.013. Epub 2015 Jan 8.

Fusobacterium nucleatum: a commensal-turned pathogen.

Author information

1
Division of Periodontics, Section of Oral Diagnostics & Sciences, College of Dental Medicine, Columbia University Medical Center, United States; Department of Microbiology & Immunology, College of Physicians & Surgeons, Columbia University Medical Center, United States; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, United States. Electronic address: Ywh2102@columbia.edu.

Abstract

Fusobacterium nucleatum is an anaerobic oral commensal and a periodontal pathogen associated with a wide spectrum of human diseases. This article reviews its implication in adverse pregnancy outcomes (chorioamnionitis, preterm birth, stillbirth, neonatal sepsis, preeclampsia), GI disorders (colorectal cancer, inflammatory bowel disease, appendicitis), cardiovascular disease, rheumatoid arthritis, respiratory tract infections, Lemierre's syndrome and Alzheimer's disease. The virulence mechanisms involved in the diseases are discussed, with emphasis on its colonization, systemic dissemination, and induction of host inflammatory and tumorigenic responses. The FadA adhesin/invasin conserved in F. nucleatum is a key virulence factor and a potential diagnostic marker for F. nucleatum-associated diseases.

PMID:
25576662
PMCID:
PMC4323942
DOI:
10.1016/j.mib.2014.11.013
[Indexed for MEDLINE]
Free PMC Article

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