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Cell Stem Cell. 2015 Jan 8;16(1):9-10. doi: 10.1016/j.stem.2014.12.007.

F-class cells: new routes and destinations for induced pluripotency.

Author information

1
The Helen L. and Martin S. Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, NYU School of Medicine, New York, NY 10016, USA.
2
The Helen L. and Martin S. Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, NYU School of Medicine, New York, NY 10016, USA. Electronic address: matthias.stadtfeld@med.nyu.edu.
3
Division of Hematology/Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medical College, New York, NY 10021, USA. Electronic address: efa2001@med.cornell.edu.

Abstract

A series of five related publications describe an alternative pluripotent state that is dependent on continuous high levels of exogenous reprogramming factor expression. A comprehensive effort to molecularly compare the acquisition of this state to induced pluripotency aims at providing new insights into the mechanisms underlying cellular reprogramming.

PMID:
25575077
DOI:
10.1016/j.stem.2014.12.007
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