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Mol Cell. 2015 Jan 8;57(1):3-5. doi: 10.1016/j.molcel.2014.12.032.

SLX4: not SIMply a nuclease scaffold?

Author information

1
Ubiquitin Signaling Group, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
2
Ubiquitin Signaling Group, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark. Electronic address: niels.mailand@cpr.ku.dk.

Abstract

In this issue, Guervilly et al. (2015) and Ouyang et al. (2015) identify SUMO-interacting motifs (SIMs) in the SLX4 DNA repair nuclease scaffold protein that promote its functions in genome stability maintenance pathways independently of its ubiquitin-binding properties.

PMID:
25574947
DOI:
10.1016/j.molcel.2014.12.032
[Indexed for MEDLINE]
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