Format

Send to

Choose Destination
Molecules. 2015 Jan 7;20(1):754-79. doi: 10.3390/molecules20010754.

Pharmacological profile of xanthohumol, a prenylated flavonoid from hops (Humulus lupulus).

Author information

1
Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China. lmouc@hotmail.com.
2
Department of Science, Systems and Models, Roskilde University, P.O. Box 260, DK-4000 Roskilde, Denmark. poulerik@ruc.dk.
3
Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China. wanggenzhu_890813@163.com.
4
Institute for Nutritional Sciences, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China. qiulin@sibs.ac.cn.
5
State Key Laboratory of Biological Fermentation Engineering of Beer, Qingdao 266061, China. 15133634098@163.com.
6
State Key Laboratory of Biological Fermentation Engineering of Beer, Qingdao 266061, China. yinhua@tsingtao.com.cn.
7
State Key Laboratory of Biological Fermentation Engineering of Beer, Qingdao 266061, China. qianzh@tsingtao.com.cn.
8
State Key Laboratory of Biological Fermentation Engineering of Beer, Qingdao 266061, China. yangmei@tsingtao.com.cn.
9
State Key Laboratory of Biological Fermentation Engineering of Beer, Qingdao 266061, China. miaojinlai@fio.org.cn.

Abstract

The female inflorescences of hops (Humulus lupulus L.), a well-known bittering agent used in the brewing industry, have long been used in traditional medicines. Xanthohumol (XN) is one of the bioactive substances contributing to its medical applications. Among foodstuffs XN is found primarily in beer and its natural occurrence is surveyed. In recent years, XN has received much attention for its biological effects. The present review describes the pharmacological aspects of XN and summarizes the most interesting findings obtained in the preclinical research related to this compound, including the pharmacological activity, the pharmacokinetics, and the safety of XN. Furthermore, the potential use of XN as a food additive considering its many positive biological effects is discussed.

PMID:
25574819
PMCID:
PMC6272297
DOI:
10.3390/molecules20010754
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Multidisciplinary Digital Publishing Institute (MDPI) Icon for PubMed Central
Loading ...
Support Center