Format

Send to

Choose Destination
Med Sci Sports Exerc. 2015 Sep;47(9):1814-24. doi: 10.1249/MSS.0000000000000612.

Treadmill Running Reverses Cognitive Declines due to Alzheimer Disease.

Author information

1
1College of Sport Science, Sungkyunkwan University, Suwon, REPUBLIC OF KOREA; 2Department of Biological Sciences, Sungkyunkwan University, Suwon, REPUBLIC OF KOREA; and 3College of Engineering, Sangmyung University, Cheonan, REPUBLIC OF KOREA.

Abstract

PURPOSE:

This study investigated the effect of treadmill running on cognitive declines in the early and advanced stages of Alzheimer disease (AD) in 3xTg-AD mice.

METHODS:

At 4 months of age, 3xTg-AD mice (N = 24) were assigned to control (AD + CON, n = 12) or exercise (AD + EX, n = 12) group. At 24 months of age, 3xTg-AD mice (N = 16) were assigned to AD + CON (n = 8) or AD + EX (n = 8) group. The AD + EX mice were subjected to treadmill running for 12 wk. At each pathological stage, the background strain mice were included as wild-type control (WT + CON, n = 8-12).

RESULTS:

At the early stage of AD, 3xTg-AD mice had impaired short- and long-term memory based on Morris water maze along with higher cortical Aβ deposition, higher hippocampal and cortical tau pathology, and lower hippocampal and cortical PSD-95 and synaptophysin. A 12-wk treadmill running reversed the impaired cognitive declines and significantly improved the tau pathology along with suppression of the decreased PSD-95 and synaptophysin in the hippocampus and cortex. At the advanced stage of AD, 3xTg-AD mice had impaired short- and long-term memory along with higher levels of Aβ deposition, soluble Aβ1-40 and Aβ1-42, tau pathology, and lower levels of brain-derived neurotrophic factor, PSD-95, and synaptophysin in the hippocampus and cortex. A 12-wk treadmill running reversed the impaired cognitive declines and significantly improved the Aβ and tau pathology along with suppression of the decreased synaptic proteins and brain-derived neurotrophic factor in the hippocampus and cortex.

CONCLUSIONS:

The current findings suggest that treadmill running provides a nonpharmacological means to combat cognitive declines due to AD pathology.

PMID:
25574797
DOI:
10.1249/MSS.0000000000000612
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wolters Kluwer
Loading ...
Support Center