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Chem Commun (Camb). 2015 Mar 28;51(25):5326-9. doi: 10.1039/c4cc08613a.

Determination of receptor specificities for whole influenza viruses using multivalent glycan arrays.

Author information

1
Department of Chemistry and Biochemistry, University of California San Diego, 9500 Gilman Drive, San Diego, CA 92093-0358, USA. kgodula@ucsd.edu.

Abstract

Influenza viruses bind to mucosal glycans to gain entry into a host organism and initiate infection. The target glycans are often displayed in multivalent arrangements on proteins; however, how glycan presentation influences viral specificity is poorly understood. Here, we report a microarray platform approximating native glycan display to facilitate such studies.

PMID:
25574528
PMCID:
PMC4359031
DOI:
10.1039/c4cc08613a
[Indexed for MEDLINE]
Free PMC Article

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