Format

Send to

Choose Destination
Biomed Opt Express. 2014 Nov 5;5(12):4162-70. doi: 10.1364/BOE.5.004162. eCollection 2014 Dec 1.

Terahertz spectroscopic imaging and properties of gastrointestinal tract in a rat model.

Author information

1
Yonsei Institute of Convergence Technology, Yonsei University, Seoul 120-752, South Korea.
2
YUMS-KRIBB Medical Convergence Research Institute, College of Medicine, Yonsei University, Seoul 120-752, South Korea.
3
Graduate Program for Nanomedical Science, Yonsei University, Seoul 120-749 South Korea.
4
Department of Physics, University of Seoul, Seoul 130-743, South Korea.
5
Divsion of Advanced Materials Engineering, Chonbuk National University, Jeonju 561-756, South Korea ; Nano Materials Evaluation Center, Korea Research Institute of Standards and Science, Daejeon 305-340, South Korea.
6
Nano Materials Evaluation Center, Korea Research Institute of Standards and Science, Daejeon 305-340, South Korea.
7
Division of Electrical and Electronics Engineering, Korea Maritime University, Busan 606-791, South Korea.
8
YUMS-KRIBB Medical Convergence Research Institute, College of Medicine, Yonsei University, Seoul 120-752, South Korea ; Department of Radiology, Severance Biomedical Science Institute, College of Medicine, Yonsei University, Seoul 120-752, South Korea.
9
Yonsei Institute of Convergence Technology, Yonsei University, Seoul 120-752, South Korea ; Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul 120-749, South Korea.
10
Department of Medicine, College of Medicine, Yonsei University, Seoul 120-752, South Korea ; sklee@yuhs.ac.
11
YUMS-KRIBB Medical Convergence Research Institute, College of Medicine, Yonsei University, Seoul 120-752, South Korea ; issac@yuhs.ac.

Abstract

We have investigated basic properties of normal gastrointestinal (GI) tract tissues, including glandular stomach (GS), fore stomach (FS), large intestine (LI), small intestine (SI), and esophagus (ESO), from a rat model using terahertz (THz) reflection imaging and spectroscopy. The THz images collected from stratified squamous epithelia (SSE) of FS and ESO show a lower peak-to-peak value compared to those from columnar epithelia (CE) of GS, LI, or SI because the SSE contains less water than CE. The refractive index and absorption coefficient of FS were less than those of GS or LI, both having values similar to those of water. Additionally, we report internal reflection THz signals from ESO, although we were unable to determine the exact interface for this internal reflection.

KEYWORDS:

(170.3880) Medical and biological imaging; (170.6510) Spectroscopy, tissue diagnostics; (170.6795) Terahertz imaging; (300.6495) Spectroscopy, terahertz

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center