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Blood Purif. 2014;38(3-4):244-52. doi: 10.1159/000366124. Epub 2015 Jan 6.

Lower serum magnesium is associated with cardiovascular risk factors and mortality in haemodialysis patients.

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1
Nephrocare - Vila Franca de Xira - Dialysis Unit, Vila Franca de Xira, Portugal.

Abstract

BACKGROUND:

Hypomagnesaemia is a cardiovascular (CV) risk factor in the general population. The aim of this study was to evaluate the relationship between pre-dialysis magnesium (Mg) and CV risk markers, [including pulse pressure (PP), left ventricular mass index (LVMI) and vascular calcifications (VC)], and mortality in haemodialysis (HD) patients.

METHODS:

We performed a 48-month prospective study in 206 patients under pre-dilution haemodiafiltration with a dialysate Mg concentration of 1 mmol/l.

RESULTS:

Lower Mg concentrations were predictors of an increased PP (≥65 mm Hg) (p = 0.002) and LVMI (≥140 g/m(2)) (p = 0.03) and of a higher VC score (≥3) (p = 0.01). Patients with Mg <1.15 mmol/l had a lower survival at the end of the study (p = 0.01). Serum Mg <1.15 mmol/l was an independent predictor of all-cause (p = 0.01) and CV mortality (p = 0.02) when adjusted for multiple CV risk factors.

CONCLUSIONS:

Lower Mg levels seem to be associated with increased CV risk markers, like PP, LVMI and VC, and with higher mortality in HD patients.

PMID:
25573320
DOI:
10.1159/000366124
[Indexed for MEDLINE]
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