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Brain Struct Funct. 2016 Apr;221(3):1427-42. doi: 10.1007/s00429-014-0982-7. Epub 2015 Jan 9.

Core brain networks interactions and cognitive control in internet gaming disorder individuals in late adolescence/early adulthood.

Yuan K1,2, Qin W3,4, Yu D5, Bi Y1,2, Xing L1,2, Jin C6, Tian J1,2,7.

Author information

1
School of Life Science and Technology, Xidian University, Xi'an, 710071, Shaanxi, People's Republic of China.
2
Engineering Research Center of Molecular and Neuro Imaging Ministry of Education, Xi'an, People's Republic of China.
3
School of Life Science and Technology, Xidian University, Xi'an, 710071, Shaanxi, People's Republic of China. chinwei628@gmail.com.
4
Engineering Research Center of Molecular and Neuro Imaging Ministry of Education, Xi'an, People's Republic of China. chinwei628@gmail.com.
5
Information Processing Laboratory, School of Information Engineering, Inner Mongolia University of Science and Technology, Baotou, 014010, Inner Mongolia, People's Republic of China.
6
Department of Medical Imaging, the First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, People's Republic of China.
7
Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, People's Republic of China.

Abstract

Regardless of whether it is conceptualized as a behavioral addiction or an impulse-control disorder, internet gaming disorder (IGD) has been speculated to be associated with impaired cognitive control. Efficient cognitive behavior involves the coordinated activity of large-scale brain networks, however, whether the interactions among these networks during resting state modulated cognitive control behavior in IGD adolescents remain unclear. Twenty-eight IGD adolescents and twenty-five age-, gender-, and education-matched healthy controls participated in our study. Stroop color-word task was conducted to evaluate the cognitive control deficits in IGD adolescents. Functional connectivity and Granger Causal Analysis were employed to investigate the functional and effective connections within and between the salience, central executive, and default mode networks. Meanwhile, diffusion tensor imaging was used to assess the structural integrity of abnormal network connections. The abnormal functional connectivity within central executive networks and effective connectivity within salience network in IGD adolescents were detected. Moreover, the inefficient interactions between these two brain networks were observed. In addition, we identified reduced fractional anisotropy in salience network, right central executive network tracts, and between-network (the anterior cingulate cortex-right dorsolateral prefrontal cortex tracts) pathways in IGD individuals. Notably, we observed a significant correlation between the effective and structural connection from salience network to central executive network and the number of errors during incongruent condition in Stroop task in both IGD and control subjects. Our results suggested that impaired cognitive control in IGD adolescents is likely to be mediated through the abnormal interactions and structural connection between intrinsic large-scale brain networks.

KEYWORDS:

Central executive network; Cognitive control; Default mode network; Internet gaming disorder; Salience network

PMID:
25573247
DOI:
10.1007/s00429-014-0982-7
[Indexed for MEDLINE]

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