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Clin Infect Dis. 2015 Mar 15;60(6):919-23. doi: 10.1093/cid/ciu912. Epub 2015 Jan 7.

Diagnosis of neuroinvasive astrovirus infection in an immunocompromised adult with encephalitis by unbiased next-generation sequencing.

Author information

1
Department of Laboratory Medicine, University of California, San Francisco UCSF-Abbott Viral Diagnostics and Discovery Center, San Francisco, California.
2
Departments of Clinical Hematology.
3
Clinical Microbiology.
4
Neuropathology.
5
Research Department of Infection, Division of Infection and Immunity, University College London, United Kingdom.
6
Neurology, University College London Hospitals NHS Foundation Trust.
7
Department of Laboratory Medicine, University of California, San Francisco UCSF-Abbott Viral Diagnostics and Discovery Center, San Francisco, California Department of Medicine, Division of Infectious Diseases, University of California, San Francisco.

Abstract

Metagenomic next-generation sequencing (NGS) was used to diagnose an unusual and fatal case of progressive encephalitis in an immunocompromised adult presenting at disease onset as bilateral hearing loss. The sequencing and confirmatory studies revealed neuroinvasive infection of the brain by an astrovirus belonging to a recently discovered VA/HMO clade.

KEYWORDS:

VA/HMO astrovirus clade; deafness; encephalitis; next-generation sequencing; pathogen discovery

PMID:
25572898
PMCID:
PMC4345816
DOI:
10.1093/cid/ciu912
[Indexed for MEDLINE]
Free PMC Article

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