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FEBS Lett. 1989 Dec 18;259(1):213-6.

A single point mutation confers tetrodotoxin and saxitoxin insensitivity on the sodium channel II.

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1
Department of Medical Chemistry, Kyoto University Faculty of Medicine, Japan.

Abstract

A single point mutation of the rat sodium channel II reduces its sensitivity to tetrodotoxin and saxitoxin by more than three orders of magnitude. The mutation replaces glutamic acid 387 with a glutamine and has only slight effects on the macroscopic current properties, as measured under voltage-clamp in Xenopus oocytes injected with the corresponding cDNA-derived mRNA.

PMID:
2557243
DOI:
10.1016/0014-5793(89)81531-5
[Indexed for MEDLINE]
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