Format

Send to

Choose Destination
FEBS Lett. 1989 Dec 4;258(2):255-8.

HSV infection induces increased transcription of Alu repeated sequences by RNA polymerase III.

Author information

1
Department of Biochemistry, University College and Middlesex School of Medicine, London, England.

Abstract

The Alu family of repeated sequences is transcribed by both RNA polymerase II and RNA polymerase III. In cells infected with HSV, transcription by polymerase III increases while transcription by polymerase II decreases. By using virus strains carrying mutations in the genes encoding individual regulatory proteins, we have shown that this effect is dependent upon the immediate-early protein ICP27 and occurs by a process distinct from those which regulate viral gene expression. This is the first example of increased transcription of endogenous cellular sequences by RNA polymerase III during infection with a DNA virus.

PMID:
2557237
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center