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Trends Cell Biol. 2015 Apr;25(4):234-40. doi: 10.1016/j.tcb.2014.12.006. Epub 2015 Jan 5.

Integrins and cancer: regulators of cancer stemness, metastasis, and drug resistance.

Author information

1
Department of Pathology and the Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA.
2
Department of Pathology and the Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA. Electronic address: cheresh@scripps.edu.

Abstract

Interactions between cancer cells and their surroundings can trigger essential signaling cues that determine cell fate and influence the evolution of the malignant phenotype. As the primary receptors involved in cell-matrix adhesion, integrins present on the surface of tumor and stromal cells have a profound impact on the ability to survive in specific locations, but in some cases, these receptors can also function in the absence of ligand binding to promote stemness and survival in the presence of environmental and therapeutic stresses. Understanding how integrin expression and function is regulated in this context will enable the development of new therapeutic approaches to sensitize tumors to therapy and suppress their metastatic phenotype.

KEYWORDS:

cancer; drug resistance; integrins; stemness

PMID:
25572304
PMCID:
PMC4380531
DOI:
10.1016/j.tcb.2014.12.006
[Indexed for MEDLINE]
Free PMC Article

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