Computed tomographic features predictive of local recurrence in patients with early stage lung cancer treated with stereotactic body radiation therapy

Clin Imaging. 2015 Mar-Apr;39(2):254-8. doi: 10.1016/j.clinimag.2014.12.005. Epub 2014 Dec 12.

Abstract

Introduction: The objective of this study is to identify computed tomography (CT) features of local recurrence (LR) after stereotactic body radiation therapy (SBRT) for lung cancer.

Methods: Two hundred eighteen patients underwent SBRT for lung cancer from January 1st, 2006 to March 1st, 2011. Signs of LR recorded: opacity with new bulging margin, opacification of air bronchograms, enlarging pleural effusion, new or enlarging mass, and increased lung density at the treatment site.

Results: A new bulging margin at the treatment site was the only feature significantly associated with LR (P<.005).

Conclusion: Most CT features classically associated with LR following conventional radiation therapy are unreliable for predicting LR following SBRT.

Keywords: Computed tomography; Local recurrence; Lung cancer; Stereotactic body radiation therapy.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adenocarcinoma / diagnostic imaging*
  • Adenocarcinoma / surgery
  • Aged
  • Aged, 80 and over
  • Carcinoma, Squamous Cell / diagnostic imaging*
  • Carcinoma, Squamous Cell / surgery
  • Female
  • Humans
  • Lung / diagnostic imaging*
  • Lung / surgery
  • Lung Neoplasms / diagnostic imaging*
  • Lung Neoplasms / surgery
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local / diagnostic imaging*
  • Radiosurgery
  • Tomography, X-Ray Computed / methods