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Molecules. 2015 Jan 6;20(1):683-92. doi: 10.3390/molecules20010683.

Salvianolic acid Y: a new protector of PC12 cells against hydrogen peroxide-induced injury from Salvia officinalis.

Author information

1
Department of Technology Development, TianJin Tasly Pride Pharmaceutical Co., Ltd., Tianjin 300410, China. gongjun_1986@126.com.
2
Department of Technology Development, TianJin Tasly Pride Pharmaceutical Co., Ltd., Tianjin 300410, China. juach@tasly.com.
3
Department of Technology Development, TianJin Tasly Pride Pharmaceutical Co., Ltd., Tianjin 300410, China. zhoudz@tasly.com.
4
Department of Technology Development, TianJin Tasly Pride Pharmaceutical Co., Ltd., Tianjin 300410, China. lidekun@tasly.com.
5
Tasly R&D Institute, Tasly Pharmaceutical Co., Ltd., Tianjin 300410, China. wzhou@tasly.com.
6
Tasly R&D Institute, Tasly Pharmaceutical Co., Ltd., Tianjin 300410, China. 1122gengwanli@163.com.
7
Department of Technology Development, TianJin Tasly Pride Pharmaceutical Co., Ltd., Tianjin 300410, China. libing3@tasly.com.
8
Department of Technology Development, TianJin Tasly Pride Pharmaceutical Co., Ltd., Tianjin 300410, China. lili4@tasly.com.
9
Department of Technology Development, TianJin Tasly Pride Pharmaceutical Co., Ltd., Tianjin 300410, China. liuyanjie@tasly.com.
10
Department of Technology Development, TianJin Tasly Pride Pharmaceutical Co., Ltd., Tianjin 300410, China. heying@tasly.com.
11
Department of Technology Development, TianJin Tasly Pride Pharmaceutical Co., Ltd., Tianjin 300410, China. songmeizhen2013@tasly.com.
12
Department of Technology Development, TianJin Tasly Pride Pharmaceutical Co., Ltd., Tianjin 300410, China. wangyunhua@tasly.com.
13
Department of Technology Development, TianJin Tasly Pride Pharmaceutical Co., Ltd., Tianjin 300410, China. yezl@tasly.com.
14
School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100050, China. linrc68@163.com.

Abstract

Salvianolic acid Y (TSL 1), a new phenolic acid with the same planar structure as salvianolic acid B, was isolated from Salvia officinalis. The structural elucidation and stereochemistry determination were achieved by spectroscopic and chemical methods, including 1D, 2D-NMR (1H-1H COSY, HMQC and HMBC) and circular dichroism (CD) experiments. The biosynthesis pathway of salvianolic acid B and salvianolic acid Y (TSL 1) was proposed based on structural analysis. The protection of PC12 cells from injury induced by H2O2 was assessed in vitro using a cell viability assay. Salvianolic acid Y (TSL 1) protected cells from injury by 54.2%, which was significantly higher than salvianolic acid B (35.2%).

PMID:
25569522
DOI:
10.3390/molecules20010683
[Indexed for MEDLINE]
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